Sentences with phrase «reduction of amyloid protein»

The research that was carried out on the mice showed a dramatic reduction of amyloid protein in the visual cortices of the animals after just one hour of being under the light.

Not exact matches

Additional experiments with cultured cells suggested that the mutation interferes with one of the enzymes that breaks down the APP protein and causes a 40 % reduction in β amyloid formation, Stefansson and colleagues report online today in Nature.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

The resulting amyloid - β reductions in gamma - stimulated animals were likely due both to lower production of the protein and to microglia clearing more of it away, the authors wrote.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

A substudy from one of the outpatient obesity trials found that both the low - carbohydrate and low - fat diets led to reductions in C - reactive protein and plasma serum amyloid A (85).

There are precedents that parallel our apparently paradoxical finding.36, 37 In a β - amyloid immunization trial among those with probable Alzheimer disease, immunization led to significant clinical benefit, reduced β - amyloid load, and reduced brain volume.36 The investigators hypothesized that removal of β - amyloid and / or other protein constituents from brain tissue may have caused cerebral fluid shifts, resulting in brain volume reductions on magnetic resonance imaging.