Sentences with phrase «reduction of huntingtin»
Edited to clarify the difference between complete reduction of huntingtin in the mouse experiments, as opposed to partial reduction by huntingtin - lowering drugs
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Huntingtin null neurons exhibit a significant reduction in transcripts encoding proteins destined for the extracellular space, many of which are components of the extracellular matrix or involved in cellular adhesion, receptor binding and hormone activity.
We think the most exciting news in today's press release from Ionis is this: «In the Phase 1 / 2a study, dose - dependent reductions of muntant huntingtin were observed among patients treated with IONIS - HTTRx».
In addition, HDAC4 reduction delayed huntingtin (Htt) aggregation in CNS tissue from both the R6 / 2 and HdhQ150 full length KI mouse model of HD [1].