Using simulations, we show Karp is accurate across a variety of read lengths,
reference sequence lengths, sample depths, and when samples contain reads originating from organisms absent from the reference.
Not exact matches
Using SHIMS, the lab greatly improved the human X
reference sequence, accurately assembling three large amplicons, identifying previously unknown palindromes, and ultimately shortening the entire
length of the
sequence by eliminating four major gaps.
Using simulations, we show the method is accurate across a variety of read
lengths, with different
length reference sequences, at different sample depths, and when samples contain reads originating from organisms absent from the
reference.
(A) Full -
length genome
sequence of SARSr - CoV Rs4084 was used as query
sequence and RsSHC014, Rf4092 and Rs4081 as
reference sequences.