"Refractory" is an adjective that describes something or someone who is stubborn, resistant, or difficult to control or change.
Full definition
A level 3 center provides the basic range of medical, neuropsychological, and psychosocial services needed to treat patients
with refractory epilepsy.
As a staged procedure, laser ablation surgery is also helpful in the long term treatment
of refractory cases of feline chronic gingivostomatitis.
At 12 months, they reported similar improvements in seizure control confirming that the KD for use in
refractory epilepsy in children is an acceptable treatment of choice (10).
Psychologists have long been puzzled by the psychological
refractory period because it doesn't fit with other things we know about how the brain works.
These data are featured in an article titled, «P2X3 Receptor Antagonist (AF - 219)
in Refractory Chronic Cough: A Randomised, Double - Blind, Placebo - Controlled Phase 2 Study,» which is appearing online in The Lancet.
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According to the trial's crossover design, patients with
refractory chronic cough of at least eight weeks» duration were randomly assigned initially to either AF - 219 or placebo treatment twice daily for two weeks, followed by a washout period, and further followed by crossover to the alternative treatment arm (AF - 219 or placebo) for an additional two weeks.
This is a rare type of cancer but the findings could be of real benefit to this small but important group of patients with
refractory celiac disease.»
«The prognosis for patients with
refractory cardiac arrest with long resuscitation attempts has previously been shown to be poor.
Pomalidomide plus low - dose dexamethasone administered in combination has shown efficacy in patients with relapsed or
refractory myeloma who have normal kidney function or moderate renal impairment.
«Empliciti represents a fundamentally different approach of directly activating the immune system in patients with relapsed or
refractory multiple myeloma, delivering improved outcomes for those in need,» a BMS spokeswoman told Business Insider in an email.
I have found in
refractory cases a hypoallergenic diet is helpful in controlling the problem.
Neurologists successfully
treat refractory epilepsy patients with a special brain surgery that removes small sections of the brain where seizures occur.
Diagnosis and Management of
Refractory Diarrhea Colin F. Burrows, BVetMed, PhD, MRCVS, DACVIM University of Florida, College of Veterinary Medicine Gainesville, FL, USA
After seeing promising results in phase 1 of the Pediatric Leukemia Adoptive Therapy (PLAT - 02) trial with 93 percent of patients with relapsed or
refractory acute lymphoblastic leukemia (ALL) achieving complete initial remission, researchers at Seattle Children's are continuing their quest to improve the experimental therapy and reduce the rate of relapse, which is about 50 percent.
ECT has been proven effective in severe depression and
refractory pain syndromes — its impact is in the brain itself, where it seems to reset thresholds of reactivity.
«Patients with rheumatoid arthritis often
become refractory to treatment provoking the need to try different drugs targeting different pathways,» said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.
For a diagnosis of
refractory sprue, all other possible causes of the intestinal damage must be eliminated.
Improved quality of life and seizure control in children with
medically refractory seizures can be achieved with ketogenic diet treatment.
If approved by the FDA in October for the treatment of
refractory melanoma, pembrolizumab would be the first PD - 1 checkpoint inhibitor approved in its class, beating out BMS's nivolumab in the race to the finish line — or starting line, really, since both drugs will likely have multiple future uses.
Despite its current surge in popularity, the ketogenic diet has been around for a long time and is commonly used for
refractory seizure disorders (epilepsy).
Anti-PD-1 antibody therapy enhances eradication of
refractory Hodgkin lymphoma (HL), and when used in combination with other agents may help improve outcomes for leukemia patients, according to a report in the journal Leukemia Research.
In a presentation by Dr. Sheri Ross at the 2006 meeting of the American College of Veterinary Internal Medicine, she noted that in one study of dogs and cats with naturally occurring kidney failure, two of three dogs treated with erythropoietin for greater than 90 days and five of seven cats treated for greater than 180 days
developed refractory anemia that was attributed to anti-erythropoietin antibodies.
However, on page 1391 in this issue, Yun et al. (5) show that high doses of vitamin C selectively kill colorectal cancer cells carrying activating mutations in the oncogenes KRAS or BRAF, which are
often refractory to approved targeted therapies.
In current commercial tower CSP projects, this area is clad in a heat shield of high - temperature
refractory materials above and below the receiver to protect the headers and other infrastructure components from heat damage from solar flux spillage.
In consequence, his moral appeal was habitually directed to individual consciences and his moral blame was visited
on refractory wills.
Efficiency and heat retention come from Sorrento
refractory brick walls AND deck that retain the heat, a low dome and balanced heat from all directions.
A Phase 3, Randomized, Open - Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed /
Refractory Diffuse Large B Cell Lymphoma (ZUMA - 7)
Breed health concerns may include bloat (gastric dilatation and volvulus), elbow and hip dysplasia, hypertrophic osteodystrophy (HOD), tricuspid dysplasia, peritoneopericardial diaphragmatic hernia, pododermatitis, generalized demodicosis, neutrophil function defect of Weimaraners, meningitis, spinal dysraphism, entropion, distichiasis, eversion of the cartilage of the nictitating membrane,
refractory corneal ulceration and von Willebrand disease.
If
refractory coeliac disease is suspected, it's likely you'll be referred for a series of tests to make sure your symptoms aren't being caused by another condition.
However, a small percentage (2 - 5 %) of patients diagnosed in adulthood does not respond to such a diet, due to long term inflammation and damage, and have what is
called refractory celiac disease (RCD).
Salutary effect of Terminalia Arjuna in patients with severe
refractory heart failure.
A phase I clinical trial of oral COL - 3, a matrix metalloproteinase inhibitor, in patients with
refractory metastatic cancer.
Dr. Mody's primary research interest includes use of precision oncology approach for designing innovative clinical trials for
refractory childhood cancers.
«The study is remarkable for the fact that four of seven patients with relapsed
refractory HL had objective clinical responses, including durable complete responses of more than 4 years.
Black carbon - Operationally defined aerosol species based on measurement of light absorption and chemical reactivity and / or thermal stability; consists of soot, charcoal and / or possible light absorbing
refractory organic matter.
Steere published a paper this year about the role of at least four autoantigens — human proteins that can produce a major immune response under certain circumstances — that have a role in persistent joint inflammation in patients with antibiotic -
refractory Lyme arthritis.
The US Food and Drug Administration (FDA) recently approved the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib for the treatment of patients with relapsed or
refractory marginal zone lymphoma who require systemic therapy and have had at least one prior anti-CD20 therapy.
Phrases with «refractory»