Sentences with phrase «reg cells»

Resistant starch also prevented loss of goblet cells in the intestinal crypts and TNF - alpha expression in the cecum and increased T - reg cells in the brain by 10-fold.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

A team of researchers led by Andreas Beilhack and Harald Wajant of the University Hospital W?rzburg devised an alternative way to prevent GvHD in mice, developing a protein called STAR2 that can stimulate the formation of the transplant recipient's own T reg cells in vivo.

STAR2 works by specifically binding to a cell surface protein called TNFR2, activating a signaling pathway that increases the number of T reg cells.

They found that administering IGF - 1 induced the production of T - reg cells, which in turn suppressed symptoms.

The research confirms that IGF - 1 acts directly on T - reg cells — rather than indirectly by affecting some other factor that induces T - reg cells to multiply.

The researchers describe the successful application of their strategy in mice in «Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion,» which will be published online August 15 ahead of issue in The Journal of Experimental Medicine.

Not exact matches

Nadeau studied immune cells called regulatory T cells, or T - regs.

To figure out the mechanism, Nadeau focused on the gene Foxp3, which spurs immature T cells to develop into those police officer cells, T - regs.

But 30 had poorly functioning T - regs that let T helper cells proliferate unchecked.

In essence, he says, weak T regs can mature into killer T cells that weed out other immune cells mounting attacks on healthy tissues.

This biosynthetic hybrid stimulates the development of weak T regs into killer T cells that destroy the immune cells directing the autoimmune attack.

At the University of Calgary's Diabetes Research Centre in Alberta, immunologist Pere Santamaria is focusing on what he calls «weak» T regs, cells that seem to have only a very feeble antigen response.

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

This «friendly fire» goes unchecked due to the failing of another type of immune cell: called the T - reg, which controls T - effector cells, shutting them down when they are not needed.

Our definition is similar to the European Medicines Agency (EMA) definition of Advanced Therapy Medicinal Product (ATMP): «Medicinal product for human use that is a gene therapy medicinal product, a somatic cell therapy medicinal product or tissue engineered product» (EMA ATMP Reg.

We have also generated T - regs (CD4 + / 25high / 127low / --RRB- in vitro from donor AD - MSC and recipient peripheral blood mononuclear cells and these T - regs are infused in thymus of renal allograft recipients after kidney transplantation.

Abbreviations: AD - MSC: adipose tissue derived mesenchymal stem cells; APC: antigen presenting cell; BM: bone marrow; CNI: calcineurin inhibitor; DC: dendritic cells; GVHD: graft - versus - host disease; HLA: histocompatibility locus antigen; HGF: hepatocyte growth factor; IL: interleukin; IDO: indoleamine 2,3 - dioxygenase; MLR: mixed lymphocyte reaction; MSC: mesenchymal stem cells; PGE2: prostaglandin E2; SC: stem cells; TGF: transforming growth factor; TH: T - helper; T - regs: T - regulatory cells.