5/15/2008 New Role Found for a Cardiac Progenitor Population In a discovery that could one day lead to an understanding of how to
regenerate damaged heart tissue, researchers at the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium — the cell l...
In the United States, about 720,000 residents experience a heart attack annually, which means that hundreds of thousands of heart patients are living with the disabling complications of heart disease who could benefit from therapies to repair and
regenerate damaged heart tissue.
Not exact matches
On average the transplanted stem cells
regenerated 40 percent of the
damaged heart tissue, said Dr. Michael Laflamme, UW assistant professor of pathology, whose team was principally responsible for generating the replacement
heart muscle cells.
«But the zebrafish
heart robustly
regenerates missing or
damaged tissue in as little as 30 to 60 days.
The zebrafish
heart robustly
regenerates missing or
damaged cardiac
tissue following a partial ventricular resection procedure in as little as 30 - 60 days.
But
heart cells never truly
regenerate in the
damaged tissue, and myofibroblasts compensate for their absence by forming a stiff, collagenous scar that interferes with the
heart's ability to maintain stable
heart rhythms and to expand and contract forcefully to pump blood.
«Our hope is to one day treat diseases like
heart failure or Parkinson's disease with drugs that help the
heart and brain
regenerate damaged areas from their own existing
tissue cells.»
By studying them, we are beginning to gain insight into human disease — to understand why organs such as the
heart can not repair themselves or why, as we age, the incidence of debilitating diseases such as cancer,
heart disease and Alzheimer's increases so rapidly, and we are developing new therapies that will enhance our abilities to
regenerate damaged tissues and prolong healthy lifespan.