«But what we are trying to do is to give the human body the necessary tools to
regenerate lost tissue — all on its own.»
That's one of the distinguishing features between stem cell therapy, which is to
regenerate lost tissue, and gene therapy, which at the moment is there to sustain cells that would otherwise die.»
The newt can
regenerate lost tissue, including heart muscle, components of its central nervous system and even the lens of its eye.
A remarkable substance extracted from pigs enables the body to
regenerate lost tissue, including fingertips and big chunks of muscle.
A research team at York has adapted the astonishing capacity of animals such as newts to
regenerate lost tissues and organs caused when they have a limb severed.
Not exact matches
But the biological secrets inside their arm regeneration feat do hold the promise of learning more about how we might better
regenerate our own diseased or
lost tissue.
Although wounds healed up as expected, with the
tissue around the cut closing up in just a few hours, the researchers noticed something unexpected: the jellyfish were not
regenerating tissues to replace the
lost arms.
Stem cells, which have to divide regularly to
regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the
tissues have fewer fresh cells and they
lose their regenerative capacity.
Previous research conducted by Dr. Badylak's team suggested that ECM also could be used to
regenerate lost muscle by placing the material in the injury site where it signals the body to recruit stem and other progenitor cells to rebuild healthy
tissue.
Rieger and other scientists working in the institution's Kathryn W. Davis Center for Regenerative Medicine study
tissue repair, regeneration and aging in a diverse range of organisms that have robust mechanisms to repair and
regenerate lost and damaged
tissues.
The hope, in the wake of Yamanaka's discovery, was that iPS cells could be a controversy - free alternative, conferring on humans a newtlike ability to
regenerate lost or diseased
tissue.
The ultimate goal of regenerative medicine is just what it sounds like: to discover how to
regenerate lost or damaged
tissue, and thereby develop not just treatments, but cures for some of the most intractable diseases, from diabetes to Parkinson's to paraplegia.
Graber will work in the institution's Kathryn W. Davis Center for Regenerative Biology and Medicine, where scientists are working to identify the molecular pathways responsible for regeneration in organisms that have retained the ability to
regenerate lost and damaged
tissues and organs, then screening for drugs with the potential to reawaken these dormant regeneration pathways in humans.
The ability to regrow limbs
lost through accident or the action of their nemesis is a power usually thought of as belonging only to comic - book heroes, but in nature the ability to
regenerate tissues and even whole limbs is surprisingly widespread across the plant and animal kingdoms.
Stem cells, which have to divide regularly to
regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with ageing: over time, the
tissues have fewer fresh cells and they
lose their regenerative capacity.
Put another way, low testosterone and the resulting low estradiol (a necessary form of estrogen in men's bodies derived from testosterone) can slow needed healthy bone regeneration, creating a gap between the amount of bone mass
lost and bone
tissue that can be
regenerated — that means bones begin to weaken.