Sentences with phrase «regenerative capacities of»

A team of paleontologists of the Museum für Naturkunde Berlin, the State University of New York at Oswego and Brown University shows in a new study of fossil amphibians that the extraordinary regenerative capacities of modern salamanders are likely an ancient feature of four - legged vertebrates that was subsequently lost in the course of evolution.

New data from the fossil record offers a new perspective on the evolution of the enormous regenerative capacities of modern salamanders.

It encourages the removal of forests and vegetation, which promotes erosion of soil and demotes the regenerative capacity of the planet.

Moreover, the regenerative capacity of corneal nerves following wounding is impaired in the corneas of diabetic patients compared to normal B6 mouse corneas.

Van Horne's trial aims to leverage the regenerative capacity of peripheral nerves to allow the brain to heal itself.

And when I look at the regenerative capacity of other tissues in the body, I think «how can we take advantage of what nature has already figured out?»»

In muscular dystrophies and muscle wasting, progressive degeneration overwhelms the regenerative capacity of adult MuSCs.

The scientists hypothesized that the regenerative capacity of the species with shorter life expectancies would decline as they aged.

MDI Biological Laboratory Associate Professor James A. Coffman, Ph.D., is studying the regenerative capacity of sea urchins in hopes that a deeper understanding of the process of regeneration, which governs the regeneration of aging tissues as well as lost or damaged body parts, will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

Cyclin A2: Increased levels of cyclin A2 have been shown to increase the regenerative capacity of heart tissue, one of an array of proteins that might for the basis for regenerative gene therapies for heart disease, and thus also might be beneficial to undergo far in advance of old age so as to slow or postpone degeneration in the heart.

Faculty Henri Jasper, PhD has already extended lifespan and healthspan in fruit flies by enhancing the regenerative capacity of the adult stem cells that line their mid-gut.

Ed Field currently is the Chief Operating Officer of Cytomedix, Inc. (OTCBB: CMXI), a US - based company that is developing and commercializing autologous regenerative biotherapies that promote healing by harnessing the innate regenerative capacity of platelets and adult stem cells.

Here at the MDI Biological Laboratory, we identified the regenerative capacity of the shark and skate almost 15 years ago.

His ultimate aim is to harness the regenerative capacity of these adult stem cells for therapeutic use.

Special impetus was put on the regenerative capacity of the adult midbrain.

Thus, they may be a way to harvest the regenerative capacity of pediatric heart tissue without delivering the cells themselves.

In 2011, researchers in Germany found that exposure to stress was responsible for alterations in gut motility, an increase in intestinal permeability, and negative effects on the intestinal microbiota, as well as the regenerative capacity of the gut mucosa.

With humanity's ecological footprint of 2.7 global hectares (gha) per person means to say that to sustain the current population on Earth of 7 billion people would take 18.9 billion gha (2.7 gha x 7 billion people) which is higher than the 13.4 billion global hectares (gha) of biologically productive land and water on Earth, a fact that indicates that already exceeded the regenerative capacity of the planet in the average level of current world consumption.

Footprint accounting is thus based on the premise that the regenerative capacity of the ecosphere is associated with productive ecosystem area.

Despite Blomqvist et al.'s reservations, Footprint results show that: (1) most countries are in ecological deficit, increasingly dependent on potentially unreliable trade in biocapacity; (2) humanity is at or beyond global carrying capacity for key categories of consumption, particularly agriculture (factoring in soil loss and ecosystem degradation would reveal additional deficits); (3) global carbon waste sinks are overflowing; and (4) the aggregate metabolism of the human economy exceeds the regenerative capacity of the ecosphere (and the ratio is increasing).

On the global scale, when the footprint of consumption exceeds biocapacity, the interpretation is that humans are exceeding the regenerative capacity of Earth's ecosystems and therefore depleting stocks of natural capital, a state known as «overshoot» [19].

After all, from the astounding biodiversity in healthy soils to the regenerative capacity of rainforests, we know that nature can handle a lot of the crap we throw at it — or at least will do a good job trying.

Its maximum power output will be 200kW equating to 270 horsepower and the vehicle will have a max regenerative capacity of 150kW, powered by the brakes as drivers enter corners and chicanes.

Not exact matches

The finding raised the possibility of harnessing this regenerative capacity to mend damaged brains, which could translate into more effective treatments for Alzheimer's and Parkinson's.

A new study by researchers at Children's Hospital Los Angeles has shown that neonatal mouse hearts have varying regenerative capacities depending upon the severity of injury.

In addition to differences in regenerative capacity, the investigators also found an indicator of tissue fibrosis or «scarring,» profibrotic marker PAI - 1, was markedly elevated only after transmural injury.

Stem cells, which have to divide regularly to regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.

The mechanisms controlling this high regenerative capacity are the focus of a large field of research driven by the hope to some day apply the findings to human medicine.

«The question that we wanted to address was, if and how this different way of developing limbs is evolutionarily linked with the high regenerative capacities.»

«The high regenerative capacities were lost in the evolutionary history of the different tetrapod lineages, at least once, but likely multiple times independently, among them also the lineage leading to mammals.»

«We were able to show salamander - like regenerative capacities in both — fossil groups that develop their limbs like the majority of modern four - legged vertebrates as well in groups with the reversed pattern of limb development seen in modern salamanders,» said Dr. Jennifer Olori of State University of New York at Oswego, co-author on the study.

We lose many of those stem cells, along with their regenerative capacity, as we age.

Some species also live to extraordinary old ages and — even more remarkably — do so with no signs of poor health, such as a decline in regenerative capacity or an increase in age - related mortality.

They studied regenerative capacity in three species of sea urchins with long, intermediate and short life expectancies: the red sea urchin, Mesocentrotus franciscanus, one of the world's longest - lived organisms with a life expectancy of more than 100 years; the purple sea urchin, Strongylocentrotus purpuratus, with a life expectancy of more than 50 years; and the variegated sea urchin, Lytechinus variegatus, with a life expectancy of only four years.

They found that although the variegated sea urchin, L. variegatus, has a much lower life expectancy in the wild than the other two species they studied, it displayed no evidence of a decline in regenerative capacity with age, which suggests that senescence may not be tied to a short life expectancy in the wild.

Stem cells are renowned for their regenerative capacity, able to grow into many different kinds of cells in the body.

Humans do have some regenerative capacities — for example, regrowing fingertips if a sizable portion of the fingernail remains.

In 2017, he took up the position of Assistant Professor at the Fox Chase Cancer Center in Philadelphia, heading his own laboratory, which focuses on how tissue and organ degeneration, regeneration defects, and decline in regenerative capacity affect the initiation of cancer.

VEGF plus Gata4, Mef 2c, and Tbx5: A fair number of research and development efforts have focused on delivery of VEGF to spur regeneration in the cardiovascular system, and particularly in the heart, an organ with only limited regenerative capacity in mammals.

Since delivering GHK on its own appears to be beneficial, using gene therapy to reset GHK levels may restore some of this loss of regenerative capacity.

Drs. King and Yin commented to OTW, «The long - term goal of our research at MDI Biological Laboratory is to understand how we may be able to enhance human regenerative capacity after injury.

I will discuss our latest results showing that satellite cells in their homeostatic quiescent state are equipped with quality control mechanisms to preserve their fitness, and how age - associate alterations in these protective mechanisms lead to stem cell loss of function and regenerative capacity.

Despite humans sharing many of these genes within these organisms, our adult regenerative capacity is limited.

In mammals, a single fertilized egg rapidly divides into several trillions of cells grouped into specialized tissues with marked differences in terms of developmental origin, regenerative capacity and ability to cope with damage.

When the heart muscle dies from lack of blood, it is replaced by scar tissue, since the heart has very little regenerative capacity.

The study of the genetic and molecular pathways underlying regeneration in these species provides insight into the dormant molecular pathways for regeneration in humans, raising the prospect therapies can be developed to trigger human regenerative capacity.

The course, which is a follow - up to the inaugural course held in 2015, will bring together students and leaders in the field from around the world to learn about the determinants of regenerative capacity, the causes of biological aging and strategies for applying what is learned to improve human health and advance regenerative medicine.

Hammadah concludes that low leukocyte telomere length is associated with decreased regenerative capacity, independently of age and cardiovascular risk factors.

They tease apart the influences of age and cardiovascular disease (CVD) risk factors on these cells, whose regenerative capacity has made them the target of much investigation.

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).