Sentences with phrase «region gene segments»

Background mutation rates by this method is ∼ 1 base - exchange per 1,000 bases sequenced (based on sequences of constant region gene segments).

Not exact matches

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Researchers used the CRISPR / Cas9 gene editing technique to introduce a segment of a human gene causing Huntington's, with a very long glutamine repeat region, into pig fibroblast cells.

To identify segments across the intronic and exonic regions of the BRCA1 or BRCA2 genes associated with different breast vs ovarian cancer risks, we created bins of mutations by base pair location (Figure 1).

The lead author, Karen Reddy, a postdoctoral fellow in the Singh laboratory, proposes that, such compartmentalization «implies the existence of DNA segments that encode for «nuclear addresses» acting like a nuclear zip code to direct or predispose genes to associate with specific regions within the nucleus.

The human T cell receptor beta (TRB, previously known as TCRB) gene locus on chromosome 7 (7q34) includes 65 Vb (variable) gene segments, followed by two separate clusters of genes each containing a Db (diversity) gene, several Jb (joining) genes, and a Cb (constant) region spread over 685 kilobases.

However, most differentiated regions contained very few annotated genes: 59 segments (57.8 %) contained three or fewer genes and 30 (29.4 %) localized to a single gene.