Sentences with phrase «region of a single gene»

Changes in the regulatory region of a single gene may have had a profound affect on human evolution.

Not exact matches

This permits high - resolution mapping of genes and chromosomal regions on single fibers of DNA, and it targets the physical location of mitochondrial DNA probes down to a resolution of 1,000 base pairs.

At a symposium at The American Society of Human Genetics here last month, they reported zooming in on the genes expressed in a single brain cell, as well as panning out to understand how genes foster connections among far - flung brain regions.

At the cellular level, although they share canonical types of inhibitory interneurons (INs) and excitatory principal neurons (PNs), it remains largely unknown to what extent a single type in different brain regions displays similarity in gene expression, axonal shape, connectivity, and developmental origins.

In their new Science paper, the researchers analyzed gene expression in single cells across key developmental time points and from different regions of the brain.

For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

OR and V1R genes typically have coding regions that span a single exon, but we identified 54 OR and 15 V1R genes where at least one of the reconstructed transcripts has an intron within the protein coding sequence (as annotated in Ensembl).

Remarkably, 30 regions were each found to contain a single gene, facilitating the identification of candidate genes underlying reproductive isolation.

(A) Expression of 5 stem marker genes in single cells isolated from the edge (E), mid (M) or adjacent center (C) region of HES2 colonies.

Single cell Q - RTPCR for the genes indicated was carried out on 87 cells isolated from different regions of ES colonies.

They found that 46 percent of breakpoints disrupted a single gene; 24 percent disrupted regions between genes; and 30 percent disrupted at least two genes.

We have used a patient cybrid cell line with a single point mutation in the overlap region of the ATP8 and ATP6 genes of the human mitochondrial genome.

Objective 1: To create a recombinant, nonanaphylactic, single - chain antibody fragment (scFv) with high affinity for canine IgE from the variable region gene sequences of mAb 5.91 clones.