Sentences with phrase «region on chromosome»

Additional markers were then analyzed in a small region on chromosome 18 showing significant linkage to the disease.

«We've identified across all populations a region on chromosome 8 that increases risk (for prostate cancer),» Kittles said.

The gene was mapped to a small region on chromosome 18, which previous studies have suggested may play a role in blood pressure regulation in humans, mice and rats.

Genome - wide TDT analysis in a localized population with a high prevalance of multiple sclerosis indicates the importance of a region on chromosome 14q».

This represents the first genetic factor outside the major histocompatibility complex (MHC) region on chromosome 6 with significant linkage to any psoriasis - related phenotype.

This revealed a 2 - Mb region on chromosome 7 that showed high homozygosity in the bsl1 - 1 mutant pool (Figure 3A).

For decades, scientists had known the genetic «neighborhood» of the mutation causing MCKD1, a 2 - million - base region on chromosome 1, but the specific mutation had remained elusive.

In a sample with 26.9 % of CXCR4 alleles disrupted, NHEJ events were detected at a frequency of 2.3 % (170/7531 reads) in an extragenic region on chromosome 12 and 0.8 % (84 / 10531) in ADAMTS17, a metalloprotease of unknown function [45].

Last November, however, a team led by Mihael Polymeropoulos of the National Human Genome Research Institute in Bethesda, Maryland, reported that the disease afflicting the Italian family, which develops at an unusually early age, showed strong genetic linkage to a region on chromosome 4.

Researchers have identified, through the analysis of samples obtained from a consanguineous Middle Eastern family, a region on chromosome 7q21 that has significant linkage with POF.

By selecting those plants with dark green shoulders and crossing them back with the cultivated varieties, they narrowed down the culprit to a region on chromosome 10.

In this study, researchers found that the Bt locus was delimited to a 442 - kb region on chromosome 5 that harbors 67 predicted genes.

She identified a region on chromosome 8 where the affected family members had distinctly different genes.

The researchers found three common genetic markers linked to a region on chromosome 4 in 30 percent of the study participants.

Feinberg focused on a region on chromosome 11, because a handful of affected patients had abnormalities there, such as DNA that was repeated or deleted.

It appears that the gene for cystic fibrosis is found in a narrow region on chromosome seven.

They found regions on chromosomes 20 and 22 that tended to be different in horses diagnosed with sarcoids, evidence that a horse's genes determine, in part, how susceptible it is to sarcoids.

Using a variety of sequencing and bioinformatics tools, chromosomal imaging and PCR technology, for the first time, they have identified a large chromosomal swap involving two regions on chromosomes 1 and 4, and showed that it prevents the proper reshuffling of its DNA in its progeny.

But additional chunks of chromosomes also associate with the condition, including at least two to three large regions on chromosome 5.

Studies of twins strongly support the genetic link to LD, pointing to regions on chromosomes 1, 2, 6, and 15.

Regions on chromosomes 5, 8 and 10 demonstrated moderate association with noise phobia, although none reached genome - wide significance [107].

Not exact matches

Among the Christians, the Roman Catholics have entire regions of their theology, liturgy, and practice that are extremely attractive to me, but considering the whole set of their theological ideas, I just can't stomach the xy - chromosomed hierarchy and the works over faith stuff (I'm with Luther on the point).

The SRY (sex - determining region Y) gene on the male's Y chromosome orchestrates the formation of the testes, while the gonadal precursor will differentiate into an ovary by default (in the absence of the steroids produced by the testes).

But in a closer study of 73 families researchers found a region of genes on chromosome eight in those with perfect pitch and from European ancestry.

Gene sequencing revealed two regions associated with major depressive disorder on one of the 23 pairs of chromosomes.

The team members narrowed their search to a region of about 1 million base pairs on chromosome 1.

Standard mapping procedures depend on homing in on informative coding regions in genes and «walking» along the chromosome, past any uninformative repetitive DNA, to the next gene.

They did so by focusing on centromeres, the region of a chromosome that attaches to the spindle.

The locus most strongly associated with severe CCD was found on chromosome 34 — a region containing three serotonin receptor genes.

King's team has narrowed the hunt to a region of just 300 000 base pairs on the chromosome.

Focusing on two stickleback species — one that dwells in the grassy shallows of the lake bottom and another that inhabits open water — the researchers found that different parts of the fish skeleton, even those that lie close to one another, are controlled by different chromosome regions.

The discovery marks the latest in a series of findings related to the protein SRY (sex - determining region on the Y chromosome), which serves as a master switch for ensuring typical human male maturation.

Previous work had implicated several genetic regions, including one on the X chromosome called Odysseus, which is expressed in the testis.

Recently there has been a particular focus on the «Kallikrein» region of chromosome 19.

The researchers pinpointed three gene regions underlying tunnel length, located on chromosomes 1, 2, and 20, and one, located on chromosome 5, that determined whether escape tunnels were made.

Chromosome fragile sites are regions of DNA double strand breaks on human chromosomes.

«We identified one genome - wide significant locus for anorexia nervosa on chromosome 12, in a region previously shown to be associated with type 1 diabetes and autoimmune disorders,» said lead investigator, Cynthia Bulik, PhD, FAED, founding director of the UNC Center of Excellence for Eating Disorders and a professor at Karolinska Institutet in Stockholm, Sweden.

Dr Siddharth Banka, Clinical Senior Lecturer at the Manchester Centre for Genomic Medicine, who led the study, explained: «Our team has identified that this new syndrome is caused by a small deletion on chromosome 6 that affects the function of hypothalamus, a region of the brain that plays a number of important roles in the body.»

When we noticed a big region with special pattern on the haplotype figure of chromosome X, we knew something must be there.»

Notably, an exceptionally large (14 Mb) and low - recombination region on the X chromosome appeared to have two distinct haplotypes in the high - and low - latitude populations, which may be possibly responsible for adaptations to cold and hot environments respectively.

Schizophrenia risk From previous studies, the researchers knew that one of the strongest genetic predictors of people's risk of schizophrenia was found within a region of DNA located on chromosome 6.

During development, chromosomes are subject to chemical changes that don't affect the nucleotide sequence but can turn genes on or off; the best known example is methylation, in which a methyl group is attached to specific DNA regions.

Researchers thought they were hot on the trail of «gay genes» in 1993, when a team led by geneticist Dean Hamer of the National Cancer Institute reported in Science that one or more genes for homosexuality had to reside on Xq28, a large region on the X chromosome.

Biologists know that compared with flies from tropical Africa, flies from temperate regions such as Europe survive longer when exposed to ethanol vapors of high concentrations, and they know it has something to do with enzymes on the flies» second chromosomes, which break down alcohol and are more active in European flies.

Interestingly, performance on the Eyes Test in males was not associated with genes in this particular region of chromosome 3.

Scientists investigated the mutation that causes the Muffs and beard characteristic in certain chicken varieties by mapping the trait to the correct location on the chromosome and sequencing that region from chickens with and without Muffs and beard.

This may be especially useful as it sheds light onto why class I genes remain on a single region on one chromosome during mammalian evolution, while class II genes do not.

The evidence suggests it does: 249 pairs of siblings were more likely to both have diabetes, or both be healthy, if they shared the same set of genetic markers in the region of the IL - 12 gene on chromosome 5.

Although geneticists had pinpointed locations on chromosomes 1, 17, 20, and X linked to the disease, disease - causing genes within these regions had remained elusive.

The gene is located on chromosome 1, an area that's been scrutinized for prostate cancer genes since 1996, when family studies revealed a link between a region of that chromosome and the disease (ScienceNOW, 21 November 1996).