Sentences with phrase «region polymorphism»

Association of attention deficit hyperactivity disorder - related psychopathology and personality traits with the serotonin transporter region polymorphism

Family - based association study of the serotonin transporter promoter region polymorphism (5 - HTTLPR) in attention deficit hyperactivity disorder

Serotonin transporter gene regulatory region polymorphism and anxiety - related traits in the Japanese

Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm

Obsessive - compulsive disorder and the promoter region polymorphism (5 - HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population

Not exact matches

Instead they search specific regions of the genome for a type of mutation known as a single nucleotide polymorphism, or SNP (pronounced «snip»).

«Individuals may overeat,» Stice and his colleagues concluded, «to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.»

To get a clearer picture of the settlement patterns, David Reich of Harvard Medical School in Boston and his colleagues compared DNA from 52 Native American populations across Canada, Greenland and Central and Southern America, focusing on variations called single - nucleotide polymorphisms (SNPs) in protein - coding and non-coding regions across the genome.

To resolve this paradox, we analyzed introns and demonstrated that these are deficient in single - nucleotide polymorphisms, as are synonymous sites in coding regions.

A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent.

To identify new genetic variations associated with different SLE phenotypes, a total of 598,258 different regions on the genome (known as single - nucleotide polymorphisms) were genotyped in a population of 482 Caucasian European SLE patients of Spanish origin recruited from the rheumatology departments of 15 Spanish university hospitals belonging to the IMID Consortium (SLE group).

In order to find out whether this polymorphism is also associated with extreme longevity, Spanish researchers performed an analysis of the frequencies of this polymorphism among centenarians and healthy adults in two independent cohorts, by geographical regions and by ethnic groups.

The teams then scanned their respective databases for single - nucleotide polymorphisms — regions where the DNA differs by one base — that were associated with being either taller or shorter than average.

However, with this technology it is not possible to identify complex structural variants and polymorphisms in repeated or low - complexity regions.

Comparative analysis of length polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) in Cercopithecidae [abstract].

For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests.

Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500 - kilobase regions in which essentially all information about common DNA variation has been extracted.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

Using the investigated neutral expectations, I then measured the physical extent of the genomic region showing an excess of neutral polymorphism due to linkage to a molecular target of balancing selection.

Hypervariable regions may result from sequencing artifacts or high copy repeat regions (such as STRs or segdups) with high degree of polymorphism.

The majority of these polymorphisms have been found to reside in non-coding genomic regions, underscoring the importance of understanding the epigenetic and transcriptional regulatory landscape as it applies to melanocyte biology and disease.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

However, response to treatment may be predicted by baseline frontal lobe blood flow, and presence of polymorphisms of the 5 - hydroxytryptamine (5 - HT)-1 a gene, the LL genotype of the serotonin transporter linked polymorphic region (5 - HTTLPR) gene, and Val / Val homozygotes of the brain - derived neurotrophic factor (BDNF) gene.

As they pointed out, the repeat occurs in a region of DRD4 associated with gene activity, so the 120/240 polymorphism may have a functional effect on the dopamine receptor.

Various biological factors at baseline appear to predict response to rTMS, including levels of certain molecular factors, blood flow in brain regions implicated in depression, electrophysiological findings, and specific genetic polymorphisms.

On the basis of 326,000 polymorphisms, we found low to moderate overall levels of differentiation between subspecies, and fewer than 200 genomic regions dispersed throughout the genome showing high differentiation consistent with a signature of reduced gene flow.

To further demarcate contiguous genomic regions of high differentiation (i.e., genomic islands of differentiation), we identified all single or consecutive windows with significantly elevated ratios of fixed differences to shared polymorphisms.

List of differentiated regions defined using the proportion of fixed differences to shared polymorphisms.

Regions of differentiated were defined both based on the proportion of fixed differences to shared polymorphisms and on a Z - score higher than three (three standard deviations departing from the median FST over all windows)-RRB-.

We obtained polymorphism and divergence data from six individuals for each of the rabbit subspecies using Illumina sequencing of genomic regions enriched by DNA hybridization on microarrays [60].

Single nucleotide polymorphism -LRB--468 Gly to A) at the promoter region of SREBP - 1c associates with genetic defect of fructose - induced hepatic lipogenesis [corrected].

The four putative - outbreak ST82 sequences fell into two clades, the two clades were separated by ca 1,700 single nt polymorphisms (SNP) s when recombination regions were included but only by 12 to 21 SNPs when these were removed.

In the present study, we used a combination of BAC clone contig construction, polymorphism analysis of DNA from congenic strains, and sequence mining of the human orthologous region to generate an integrated map of the Idd10 region on mouse chromosome 3.

Because the data do not fit theoretical null distributions, attempts to infer natural selection from polymorphism data will require genome - wide surveys of polymorphism in order to identify anomalous regions.

Associations between polymorphisms in the AHR and CYP1A1 - CYP1A2 gene regions and habitual caffeine consumption

SNPs were selected for each region based on known polymorphisms between the Boxer reference sequence and other breeds.

While sequencing the coding region we observed twelve polymorphisms by comparing the sequence of Bull Terriers to that of Boxer (sequence reference UniProtKB / TrEMBL: Q9GKK9).

In the 3» untranslated region of the DRD2 polymorphism is the site of TaqIA, which was genotyped as a single nucleotide polymorphism (SNP).

We studied the well known functional polymorphism in the 5 ′ flanking regulatory (promoter) region of the gene (SLC6A4) coding for the serotonin transporter protein.

However, researchers at the University of California — Berkeley wanted to find out if there might a genetic component that could predict how couple interactions affect marital satisfaction.5 Specifically, the team decided to look at the 5 - HTTLPR polymorphism in the promoter region of the serotonin transporter gene.

Interleukin - 10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey

This investigation examined the extent to which polymorphisms of the serotonin transporter linked promoter region (5 - HTTLPR) and the dopamine receptor D4 (DRD4) genes differentially influenced the development of attachment security and disorganization in maltreated and nonmaltreated infants at age 13 months, and the extent to which the efficacy of preventive interventions to promote attachment security were influenced by genetic variation.

In relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the gene.

Evidence from population genetics reveals greater population frequency of 5 - HTTLPR S allele carriers of the 5 - HTTLPR functional polymorphism within certain geographical regions of the world, such as East Asia (figure 1b).

We describe a common, functional C > T single nucleotide polymorphism, rs25532, located less than 150 nucleotides centromeric of the serotonin transporter - linked polymorphic region indel known as 5 - HTTLPR.

We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects.

RESULTS: Transcription of the MAOA gene in rhesus monkeys is modulated by an orthologous polymorphism (rhMAOA - LPR) in its upstream regulatory region.

Mesh terms: Aggression Analysis of Variance Animals Behavior, Animal Genetic Variation Macaca mulatta Male Maternal Deprivation Monoamine Oxidase Polymorphism, Genetic Promoter Regions, Genetic Random Allocation Social Environment