The only way the team can be sure they have grown the equivalent of a fetal brain would be to genetically test individual cells from different
regions of the organoid, and compare them to those of human fetus, says Christof Koch at the Allen Institute for Brain Science in Seattle.
Not exact matches
Within two to 12 weeks, the
organoids were sprouting additional neurons, including ones found in very specific
regions of the human cortex; glia cells including astrocytes; and neural stem cells.
Chen agrees: He said his experiment «carries much less risk
of creating animals with greater «brain power» than normal» because the human
organoid goes into «a specific
region of already developed brain.»
Scientists can't yet grow spare parts
of the human brain to fix neurological injuries or defects, but they have recently used stem cells to create brain
organoids, formations
of cells that mimic some
of the brain's
regions.
The Austrian method for making whole - brain
organoids, in particular, produced a random mix
of neural
regions laid out in a topsy - turvy manner.
During observation and analysis
of the now in vivo
organoids, study authors looked for signs
of posterior
region enteroendocrine cells, which make hormones found in naturally developed human colon.
Organoids grown from the cells
of a patient carrying the gene for severe microcephaly, however, didn't grow as large because those brain
regions didn't develop properly.
Called cortical spheroids, they differ from cerebral
organoids in that the former mimic specific
regions of the brain, such as the front, rather than many sections.