Sentences with phrase «regulate t cell»

In addition, they have not only the ability to secrete immunosuppressive cytokines that regulate T cell function, but they also have the capacity to suppress the cytotoxic effects of natural killer cells.

CRK proteins selectively regulate T cell migration into inflamed tissues.

Subsequent tests revealed that the retrovirus used to ferry the corrective gene into the DNA of blood - making cells in the bone marrow had lodged in or near a gene that regulates T cells, possibly prompting their uncontrolled growth.

PKC$ þeta $ Regulates T Cell Motility via Ezrin - Radixin - Moesin Localization to the Uropod.

«We knew that TET proteins were involved in human cancer but we didn't know how they regulated T cell development,» says Angeliki Tsagaratou, Ph.D., an instructor in the Rao lab and the study's first author.

Dr. Freeman's laboratory focuses on the identification and function of T cell costimulatory and coinhibitory pathways in regulating T cell activation and application of this knowledge to the development of more effective immunotherapies for cancer, infections, asthma, and autoimmune diseases.

Dr. Sharpe's functional analysis of costimulatory pathways regulating T cell activation has led to understanding of (1) the roles of B7 - 1 and B7 - 2 as positive regulators through CD28 and (2) negative regulators through CTLA - 4, and (3) the role of PD - L1 and PD - L2 as negative regulators through PD - 1.

He did post-doctoral work on genes regulating T cell activation, first with Harvey Cantor and then Lee Nadler at the Dana - Farber Cancer Institute.

Research in Dr. Sun's laboratory is focused on understanding the mechanisms regulating T cell differentiation, and developing targeted therapeutics based on these mechanisms.

In his project, Dr. Li is investigating whether beta blockers target T cells to control breast tumor development, and is also working to understand how this pathway regulates T cell responses to tumors, which may reveal novel targets for the immunotherapy of breast cancer.

Not exact matches

Interleukin - 1 is important for developing the killer T cell response against the virus, but it also affects the part of the brain in the hypothalamus that regulates body temperature, resulting in fever and headaches.

In short - term infections such as a cold or flu, PD - 1 helps to regulate an initial strong T cell response, preventing the T cells from over proliferating and attacking the body's own cells after the infection is cleared.

Their results demonstrated shared mechanisms by which miR -17-92 mediates cGVHD progression — namely by regulating T helper - cell differentiation, B - cell activation, germinal center responses, and autoantibody production.

Based on this work, they decided to investigate whether miR -17-92 regulates T - and B - cell differentiation and function in the development of cGVHD.

In the meantime, the MUSC team, led by Yu, will continue their work and try to extend the current findings by investigating how other miRs may be involved in regulating T - and B - cell function during allogeneic BMT.

«The mechanism for how miR -17-92 regulates T - and B - cells was very consistent.

One of the four new reported loci is expected to lower the protein expression of UBASH3A, a molecule that regulates T - cell signaling and correlates with lowering the risk of primary sclerosing cholangitis.

While many protein factors are known to subtly regulate the function of T cells, David Munn and Andrew Mellor of the Medical College of Georgia in Augusta suggest that the fetus uses a cruder method to alter T cells» behaviour: starvation.

TIM - 3 is known to play a critical role in regulating the immune system, suggesting that it may be possible to target TIM - 3 on dendritic cells in order to activate T cells.

«The results show for the first time how NFkB signaling regulates the production of memory T cells during infection.

M. Rosas - Ballina and co-workers show in the same Science issue that action potentials originating in the vagus nerve regulate splenic T cells, which in turn produce acetylcholine (ACh) and intercept pro-inflammatory cytokine production (1).

HIV primarily infects CD4 T cells, which are a type of white blood cell that plays an important role in regulating the immune response.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumor develops, and how its progression is regulated,» says Ingegerd Elvers.

«We want to know what the basic function of GATA - 3 in regulating cell biology is, although it has been shown that GATA - 3 is important for the function of CD4 + T cell type to clear extracellular parasites,» said Yisong Wan, PhD, assistant professor of microbiology and immunology at the UNC School of Medicine and member of UNC Lineberger Comprehensive Cancer Center.

HIV infects so - called helper T cells, which regulate the immune response, and slowly destroys them.

The result indicates that T cells and HLA, which together regulate much of the body's immune response, gang up in a unique way to destroy narcoleptics» hypocretin cells, the team reports online this week in Nature Genetics.

The mechanism used by Notch to regulate Myc in B cells is distinct from the mechanism used in other cell types, such as T cells, where Notch also regulates Myc.

One of the most attractive features of this model is the presence of the thermolabile large T antigen, which allows the user to regulate the level of cell differentiation.

The addition of IFN - γ was used to enhance the expression of the MHC H - 2Kb class I promoter, which regulates the level of large T antigen protein in ImmortoMouse - derived cells (10).

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumour develops, and how its progression is regulated», says Ingegerd Elvers.

The mice they studied are engineered to express human leukocyte antigen, which helps regulate the human immune system, and, in this case, helped the mice produce the powerful T cells again human cancer.

T cells play a central role in regulating the cellular and humoral responses towards invading pathogens and malignant transformation.

An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve - Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

Berg, L.J. Signalling through TEC kinases regulates conventional versus innate CD8 + T - cell development.

Medical professor Christopher Rudd and his research team have identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

CD28 activation pathway regulates the production of multiple T - cell - derived lymphokines / cytokines.

JC Virus T - Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells.

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4 + T cells.

Together, these data indicate that DGKζ and Cbl - b may differentially regulate the threshold of cytokine production in CD8 + T cells.

Vitamin D up - regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4 + T cells.

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.

Cbl - b regulates antigen - induced TCR down - regulation and IFN - gamma production by effector CD8 T cells without affecting functional avidity.

Hematopoietic Lineage Cell - Specific Protein 1 Is Recruited to the Immunological Synapse by IL -2-Inducible T Cell Kinase and Regulates Phospholipase Cγ1 Microcluster Dynamics during T Cell Spreading.

Junctophilin - 4, a component of the endoplasmic reticulum — plasma membrane junctions, regulates Ca2 + dynamics in T cells.

Given the predominant role for DAG on regulating Ras / Erk and PKC - θ signaling and Cbl - b for regulating PI (3) K signaling, we hypothesized that T cells deficient in DGKζ or Cbl - b would alter TCR signal transduction through distinct mechanisms, such that DGKζ - deficient T cells would demonstrate strongly enhanced Ras / ERK activation, but only modestly enhanced NF - κB activation, and Cbl - b — deficient T cells would demonstrate modestly enhanced Ras / ERK activation and strongly enhanced NF - κB activation.

TIM - 4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen - specific T cells.

CD8 regulates T regulatory cell production of IL - 6 and maintains their suppressive phenotype in allergic lung disease.

Maria Rostovskaya (Stewart, TUD)-- «Lineage commitment of conditionally immortalized bone marrow mesenchymal stromal cells from tetracycline - regulated SV40 large t - antigen transgenic mice» (2010)

These characterizations were requisite because work by others demonstrated that expression of a constitutively active form of another DGK allele important in regulating DAG levels in T cells, DGKα, resulted in developmental blockade of T cells between progression from DN to DP (40).

PI3K regulates pleckstrin - 2 in T - cell cytoskeletal reorganization.