Sentences with phrase «regulate activity of genes»

They play a key part in regulating the activity of genes in many species, from yeast to humans Fewer than 10 years ago no one knew they existed

Histones undergo different chemical modifications that play an important role in regulating the activity of genes.

To that end, they examined in mouse embryos the global distribution of an epigenetic mark known to play a critical role in regulating the activity of genes.

Not exact matches

Genes related to the serotonin transporter, cardiac channelopathies, and the development of the autonomic nervous system are the subject of current investigation.44 The serotonin transporter recovers serotonin from the extracellular space and largely serves to regulate overall serotonin neuronal activity.

These included sites involved in regulating gene activity during brain development and initiating the transcription of genes.

By using this tool to analyze their data the scientists were able to catalogue active alleles in a comprehensive set of mouse tissues, or the mouse «Allelome,» and gain an insight into how this differential gene activity is regulated.

In addition, future work is required to understand exactly how rs9349379 regulates the activity of the EDN1 gene despite the large physical distance that separates them.

Other teams are trying to introduce the proteins encoded by the genes directly into cells, while Yamanaka is experimenting with «microRNAs» — snippets of RNA that help regulate gene activity.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

She speculates that the culprit may be a mutation located in a genome region that regulates activity of the IL - 33 gene.

They further theorized that an inhibitory feedback loop of the PER protein blocks the activity of the period gene, so the protein could prevent its own synthesis and thus regulate its own levels in a constant rhythm.

And the mutation that bestows such remarkable longevity is a gene that happens to regulate activity in the insulin / IGF signaling pathway, says Robert Schmookler - Reis of the University of Arkansas, a molecular geneticist who discovered the relationship between the mutation and the superworm's extraordinary life.

In Class I engagement, Sox9 binds to the genome indirectly via the basal transcriptional complex, regulating transcription of genes for basal cell activities.

In Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activities.

Transcription - factor genes code for proteins that regulate the activity of other genes and so affect an animal's ability to respond to its environment.

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

And the switches can either increase or decrease the activity of the genes they regulate.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

«We identified, across the genome, that enhancer RNAs were the most common type of RNA that bound to CBP, and that by making this interaction, eRNAs play a crucial role in regulating CBP activity and gene expression.»

The second insight involved changes in the evolution of gene regulation: As social complexity increased, so did the speed of changes to parts of the genome involved in regulating gene activity, located in the promoters of the genes, the researchers report.

«This is the first indication that DISC1 regulates the activity of a large number of genes, many of which are related to synapses,» Ming says.

While both species carry a core group of similar programs to regulate gene activity, the researchers found that differences appeared in specific tissue and cell types.

The HLA (human leukocyte antigen) is a system of genes responsible for regulating immune responses, and peptides are short chains of amino acids that play key roles in regulating the activities of other molecules.

In healthy cells, Arid1b is part of a bigger complex (called SWI / SNF) that regulates the activity of hundreds of genes.

The activity of each gene then was analyzed in an attempt to find the specific transcription factor responsible for regulating the conversion of sugar to starch in the above - ground portions of the plant, primarily the grains.

We can tell from its structure that the gene helps regulate the activity of other genes.

«Micro-RNA regulates the levels of the target gene's activity,» he explained.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

The activities of our genes are tightly regulated by elaborate complexes of proteins that assemble on DNA.

The researchers now intend to investigate how the different processes that regulate DNA modifications and gene activity might be linked, and which regions of the genome are initially resistant to reprogramming and why that might be.

Myc is a critical gene in governing cell proliferation and survival, activities that it carries out by regulating the expression of other genes involved in cell metabolism.

These sequences in our DNA are often situated far away from the actual genes they regulate, in comparison to so called promoter regions, which traditionally have been considered to control most of the gene activity.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

MiRNAs are molecules encoded in the genome of all animals, including humans, that regulate the activity of individual genes.

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).

Either p53 itself is mutated or there is a problem with one of the proteins that regulate p53's activity,» says the study's leader Geoffrey M. Wahl, Ph.D., a professor in the Gene Expression Laboratory.

PAk1 and CtBP1 regulate the coupling of neuronal activity to muscle chromatin and gene expression

The Pax3 protein, which is encoded by the Pax3 gene, regulates neural tube closure and cardiac neural crest development by blocking the activity of p53, which is a cell - death protein.

RPAP1 regulates the activity of RNA polymerase II by means of its interaction with gene transactivators

Specifically, they analyzed the tumors» epigenome, an array of molecules that covers the surface of DNA and helps regulate gene activity, acting like a control switch to decide which genes are active or inactive in the cell.

Temporally - and spatially - regulated transcriptional activity of the nicotinic acetylcholine receptor [beta] 4 subunit gene promoter.

DDX3 enhances the expression of p21waf1 / cip1 gene and up - regulates the promoter activity of p21waf1 / cip1 through an ATPase - dependent but helicase - independent mechanism.

Previous studies have implicated FOXM1, which encodes a transcription factor protein capable of regulating the activity of many other genes, in many other human cancers, including liver, breast, lung, prostate, colon, and pancreatic cancers.

Endowed with the power to control the activity of other genes, GTF2I might regulate signal pathways determining the structure and function of the brain or the production of neurohormones such as vasopressin and oxytoxin.

Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42

The finding suggests that these varied Wnt genes regulate Smed - beta - catenin - 1 activity to provide the positional information by which the organism specifies the location of its head and tail during regeneration.

Both encode transcription factors that help regulate the activity of other genes.