Sentences with phrase «regulate cell differentiation»
The undifferentiated stem cells were then placed onto a circular - patterned surface that served to physically regulate cell differentiation and growth.
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The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation.
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They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»
Their results demonstrated shared mechanisms by which miR -17-92 mediates cGVHD progression — namely by regulating T helper - cell differentiation, B - cell activation, germinal center responses, and autoantibody production.
Based on this work, they decided to investigate whether miR -17-92 regulates T - and B - cell differentiation and function in the development of cGVHD.
In a previous study, Professor Schmidt - Ott and his team discovered that it regulates the differentiation of epithelial cells — they line the cavities and surfaces of structures throughout the body — in the mouse embryo.
The biomedical engineers also showed that the exosomes contain miRNAs — tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation.
«This study can further our shared understanding of how the microenvironment can regulate the differentiation and fate of a progenitor or stem cell.»
MAPK regulates cell functions, including proliferation, gene expression, differentiation, cell division and a form of cell suicide known as apoptosis.
Understanding the mechanisms that regulate the self - renewal and differentiation of stem cells is important, in order that stem cells can be effectively and safely utilised in medical applications in the future.
The findings are reported in the article «A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential» published online December 15 in Genes & Development.
Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.
One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.
The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.
miRNA - 335, a messenger nucleic acid, regulates the endodermal transcription factors Sox17 and Foxa2 and is essential for the differentiation of cells within this germ layer and their demarcation from the adjacent mesoderm.
Different types of stem cells, he says, appear to have diverse ways of regulating proliferation and differentiation.
The RNAs of enhancers are expressed before the genes they regulate during human and mouse cell differentiation.
One of the most attractive features of this model is the presence of the thermolabile large T antigen, which allows the user to regulate the level of cell differentiation.
The BRAF gene is involved in regulating cell division and differentiation.
It is known to regulate genome stability and cell differentiation.
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
Dickkopf - related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.
MicroRNA - 410 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells through down - regulating Wnt3a.
Sophia Millonigg (Eckmann, MPG)-- «The translational activator complex GLD - 4 / GLS - 1 regulates germline stem cell self - renewal and differentiation in the adult C. elegans germ line» (2013)
PPARγ was initially linked to adipocyte (fat cell) differentiation, but we now know that it also regulates genes responsible for lipid uptake, accumulation, and storage of lipids in those cells.
Human as well as mouse preimplantation embryos are studied to investigate the mechanisms that regulate cell - fate, growth and differentiation.
Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.
Cell differentiation within a tissue is tightly regulated both in time and space throughout development.
The project will focus on answering the question, how an embryonic stem cell computes cues from its environment to elicit a regulated, exact cell fate choice during a process called «differentiation».
To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.
She will study how normal, healthy bone marrow stem cells find a niche and how niche environment regulates stem cell functions such as self - renewal and differentiation.
Biologically, the hair follicle is an excellent system to study complex cyclic processes like regeneration that involve regulated growth, differentiation and cell death.
In addition, the expression of other germ cell markers, such as NANOS and PIWIL1 genes, was also up - regulated as the EB differentiation progressed.
Signaling pathways / factors regulating and / or initiating ESC / iPS cells pluripotency and differentiation
He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.
Manuscripts typical of this section would describe experiments generating and analyzing lists of genes and studies of how those genes combine to regulate: differentiation of a particular cell type; cellular, tissue, or organ response to toxic / pathogenic agents; adaptation to environmental stresses.
Finally, miR - 181a was recently shown to induce neuronal differentiation and a DA phenotype in human long - term, self - renewing, neuroepithelial - like stem cells [49], which supports the potential role for miR - 181a in regulating development of mDA neurons.
Liew was first to demonstrate roles of nitric oxide within the immune system, both in the process of killing engulfed pathogens and regulating immune cell differentiation.
Research in Dr. Sun's laboratory is focused on understanding the mechanisms regulating T cell differentiation, and developing targeted therapeutics based on these mechanisms.
Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation.
iPS - RPE also down - regulate the embryonic transcription factors originally used to induce pluripotency from the somatic cell [18], suggesting differentiation away from the initial iPS phenotype.
A. Average expression levels of Global Clusters 4, 12, 15, 20 and 30 that contain up regulated transcripts during ES cell differentiation.
Most of the genes that are related to the GO functions «gland development,» «response to estrogen stimulus,» «angiogenesis,» and «mesenchymal cell differentiation» were down - regulated in intercaruncular tissue.
By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.