Sentences with phrase «regulate cell fate»
First, we find that microRNA activity is modulated during dauer in order to regulate cell fate.
http://genestogenomes.org/
We are interested in the molecular mechanisms that regulate cell fate.
A two - step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.
«We see elements of this framework of primary and secondary cell - fate determinants throughout the hematopoietic system,» said study author Harinder Singh, the Louis Block Professor of Molecular Genetics & Cell Biology and a Howard Hughes Medical Institute Investigator at the University of Chicago, «and we suspect such networks also regulate cell fate in other systems.»
«It suggests to us that targeting the pathways used in regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
Not exact matches
A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha.
The team lead by Prof. Verdon Taylor was able to demonstrate for the first time a cell - intrinsic mechanism regulating stem cell fate.
OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.
The article «EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity» has been published in Nature Cell Biology.
«This study can further our shared understanding of how the microenvironment can regulate the differentiation and fate of a progenitor or stem cell.»
«What changes a cell, or what regulates a cell to follow certain cell fate decisions?
If so, it could make cell fate more resilient to random mutations in a plant's genetic code, even when such changes keep some gene - regulating proteins from binding their intended DNA targets.
«This finding not only identifies a new mechanism that regulates totipotent stem cells, but also reveals the importance of non-coding RNAs in stem cell fate.»
Goessling and North were post-doctoral fellows in the laboratory of co-author Leonard Zon, MD, a stem cell researcher at CHB and a scientific founder of Fate Therapeutics, when they hit upon 16,16 - dimethyl PGE2 while looking for compounds that could regulate the production of hematopoietic stem cells.
Specifically, we investigate the molecular events regulating developmental decisions that instruct cardiac progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart.
Human as well as mouse preimplantation embryos are studied to investigate the mechanisms that regulate cell - fate, growth and differentiation.
Found that muscle - specific histone methyltransferases and microRNAs regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem cell fate decisions.
The project will focus on answering the question, how an embryonic stem cell computes cues from its environment to elicit a regulated, exact cell fate choice during a process called «differentiation».
Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart.
He is particularly interested in the mechanisms and molecules that regulate neural stem cell maintenance, cell fate programming and neural stem cell replacement therapies.
Genetic approaches in mouse model systems combined with cell biological assays have allowed Professor Lukas Sommer to identify mechanisms regulating stem cell fates in the developing CNS and in neural crest - derived tissues.
To achieve this that fate of these cells must be precisely regulated, such that the right number and type of cells is created at a given time and point in development.
The lab will be focused on the identification of cellular and molecular events regulating hematopoietic cell fate decisions with emphasis on DC development.