Sentences with phrase «regulate cell survival»
Retinoid - X-receptors (a / ß) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
http://www.abcam.com/
The Cosford lab employs medicinal chemistry and chemical biology approaches to probe cellular pathways that regulate cell survival pathways in deadly tumors.
Not exact matches
Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.
Contrary to current research this new study found that LKB1, a molecule that regulates the metabolism of many adult cells, is an important molecule in the cancer's promotion and survival.
They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»
PI3K is responsible for regulating the growth and survival of cancer cells and several inhibitors targeting it have already been developed.
By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.
His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.
In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.
The protein mTOR helps monitor nutrient levels in cells and regulates cell movement, protein production, and cell growth and survival.
4 «Mobile Zinc Increases Rapidly in the Retina After Optic Nerve Injury and Regulates Ganglion Cell Survival and Optic Nerve Regeneration,» January 2017, https://www.ncbi.nlm.nih.gov/pubmed/28049831
One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.
Myc is a critical gene in governing cell proliferation and survival, activities that it carries out by regulating the expression of other genes involved in cell metabolism.
HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.
Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.
In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.
Phosphoinositide Binding Differentially Regulates NHE1 Na + / H + Exchanger - dependent Proximal Tubule Cell Survival.
Current efforts focus on elucidating the role of molecular chaperones compartmentalized in mitochondria in regulating tumor bioenergetics, adaptation to cellular stress and cell survival.
Boldrini says that future research on the ageing brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.
To directly examine whether ABL kinases play a role in regulating the colonization and survival of breast cancer cells in the bone microenvironment, we injected control or ABL1 / ABL2 knockdown breast cancer cells directly into the tibia of immunodeficient mice.
Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat - Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.
Interleukin 15 (IL - 15) regulates the development, survival, and functions of multiple innate and adaptive immune cells and plays a dual role in promoting both tumor cell growth and antitumor immunity.
Pterostilbene limits the expression of the mTOR signaling pathway, which helps to regulate the growth, survival and proliferation of cells.
MAPKs (Mitogen - Activated Protein Kinases), which help the cell to respond to stress and inflammation, are vital in nature, but also regulate gene expression and survival.
On a different note, coconut oil mitigates amyloid beta toxicity in cortical neurons by up - regulating signaling of cell survival pathways (Nafar, Clarke, & Mearow, 2017).
They evaluated graviola extract and found that it contains compounds that play a role in regulating the metabolism, survival and growth of cancer cells, shrinking tumors and reducing cancerous cells» ability to grow and spread.
«It regulates cancer stem cells... the ones that allows the cancer to grow... And it plays a really prominent role in the survival of cells.»