Sentences with phrase «regulate gene expression programs»

MicroRNAs and long non-coding RNAs (lncRNAs) have the capacity to regulate gene expression programs, and their differential expression within immune cells highlights their potential in defining immune cell identity and function.

Not exact matches

These robust regulators of genetic programs comprise a novel class of small, noncoding RNAs that regulate gene expression by repressing protein translation.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

The transcriptional program of early embryonic development is tightly regulated by a set of well - defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity.

Maria Mavrikaki, PhD, has been awarded the Eleanor and Miles Shore Harvard Medical School Fellowship, established as part of a cooperative program between Harvard Medical School and McLean Hospital, to support her research on the effects of stress - and sex - regulated microRNAs on gene expression.