Sentences with phrase «regulate lipid»

Genes have been found to regulate lipid and cholesterol metabolism, while metabolic markers, such as blood sugar and insulin, are already cemented in science.

Like other members of the allium family, leeks are antimicrobial, help reduce inflammation and regulate lipid levels in the blood.

More recently, Drs. Goldstein and Brown discovered the SREBP family of membrane - bound transcription factors and the elucidation of the proteolytic pathway by which the SREBPs become activated to regulate lipid metabolism.

We further discovered that this bile acid signaling through S1PR2 and Sphingosine kinase 2 regulate lipid metabolism in hepatocytes (Nagahashi M et al, Hepatology 2015), thus play a role in development of Non-Alcoholic Fatty Liver Disease (Hylemon P et al, Hepatology 2016).

Two organs believed to regulate lipid levels are the liver and the intestine.

Intriguingly, Willer and colleagues suggest the same gene may also be involved in regulating lipid levels in the liver — a finding confirmed by the observations of a team led by Jonathan Cohen and Helen Hobbs, who propose a role for the gene in liver disease in the same issue of Nature Genetics.

PPARγ appears to be part of a network of transcription factors coordinately regulating lipid uptake and cholesterol efflux in macrophages by transcriptionally regulating the scavenger receptor CD36 and the oxysterol receptor LXRα (liver X receptor α).

They further show that, by regulating lipid metabolism, a cell is able to switch its immune phenotype by using transcriptional mechanisms and that the lipid environment has an important impact on immune cell function.

Dengue virus - induced autophagy regulates lipid metabolism.

I should also mention that this pathway regulates lipid metabolism, and this can be then regulated in insulin resistance, and that leads to this regulation of lipids and carbohydrate metabolism.

It also plays a role in regulating lipids.

Phytosphingosine is a conditioning and anti-bacterial lipid with anti-inflammatory and anti-microbial properties that regulates lipid production in the skin's outer layers and moisturizes the skin.

Not exact matches

«Hormone - producing cells are particularly susceptible to perturbed fatty acid metabolism and often have difficulties in regulating their membrane lipid composition.

The data gathered from their experiments suggest a feed - forward loop, in which tumours not only use lipids as «building blocks» to grow, but they can regulate their host's lipid metabolism to increase production of these lipids.

Changes to the properties of the lipid bilayer component of the cell membrane can alter the function of proteins embedded in the membrane — proteins that regulate critical functions such as transport of materials in and out of the cell and communication with other cells.

A research group led by Osaka University and the University of Turku has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility within lymph nodes.

A group of people at Osaka University (Eiji Umemoto [Associate Professor, Laboratory of Immune Regulation, Osaka University Graduate School of Medicine] and Masayuki Miyasaka [Specially Appointed Professor, Institute for Academic Initiatives]-RRB- and University of Turku, Finland (Akira Takeda, Postdoctoral researcher at MediCity Research Laboratory) has found for the first time that a lipid called lysophosphatidic acid (LPA) plays a vital role in regulating lymphocyte motility within lymph nodes.

Type I cells form the gas diffusing barrier and type II produce a mixture of lipids and proteins that work as a surfactant, regulating surface tension in the lungs.

Specifically, the mitochondrion is able to regulate fat synthesis (lipids) through an enzyme complex called PDC.

Thyroid hormones are involved in controlling many functions of the human body: They influence sugar, lipid and protein metabolism, regulate body temperature, heart rate, circulation and many more functions.

Thus, distribution and mobility of specific lipid species at the plasma membrane appears to precisely regulated by membrane - associated proteins.

Although the metabolic effects of osteocalcin are still being elucidated (58, 59), several studies suggest that undercarboxylated osteocalcin regulates glycemic control and lipid metabolism in mouse models (27, 30, 60).

An enzyme encoded by a single gene, for example, can regulate the synthesis of many different lipids.

We found that CD1 glycoproteins, a class of molecules responsible for the presentation of self and foreign lipids, are coordinately regulated by PPARγ activation.

He studied physiology at the University of Guelph (BSc) and completed his MSc examining the role of membrane lipids in regulating ion transport ATPases.

Identification of proteins that regulate cellular homeostasis of lipids and proteins (Carvalho group, Science 2014, J Cell Biol 2015, EMBO J 2016).

PPARγ was initially linked to adipocyte (fat cell) differentiation, but we now know that it also regulates genes responsible for lipid uptake, accumulation, and storage of lipids in those cells.

Exosome Uptake Depends on ERK1 / 2 - Heat Shock Protein 27 Signaling and Lipid Raft - mediated Endocytosis Negatively Regulated by Caveolin - 1.

When aSyn was produced at low levels, it made its way to the cell membrane and appeared to regulate chemical trafficking and metabolism of compounds called lipids — what may be normal functions for this protein.

Lipid rafts regulate lipopolysaccharide - induced activation of Cdc42 and inflammatory functions of the human neutrophil.

Endogenous galectin - 3 is localized in membrane lipid rafts and regulates migration of dendritic cells.

Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands.

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.

He studies the processes that regulate blood vessel function and response to injury, with emphasis on the role of lipid - lowering medications in preventing ischemic stroke, coronary artery disease, and heart failure.

OSBP - related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.

Specifically, the regular oscillations of other circadian genes in the brain and the liver became disrupted, as well as genes known to regulate glucose and lipid metabolism.

Patched regulates Smoothened trafficking using lipoprotein - derived lipids.

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease.

This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors.

The expression of upd2 in adult flies is up - regulated by feeding with a high - glucose or high - lipid diet.

In fact, Unpaired 2 and CCHamide - 2 produced in the fat body regulate ILP secretion from the insulin - producing cells, although their expression is regulated by carbohydrates and lipids instead of amino acids [14,15].

The results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

This is a very important - again, another transcription factor that regulates not glucose metabolism so much, but lipid metabolism and lipogenesis; and this is also under the regulation of insulin signaling cascade.

This is quite a complex pathway and I don't have time to go through details, but just briefly, glucose metabolism is regulated by insulin, so is lipid metabolism and this is one of many pathways where insulin activates a number of kinases, but particularly Akt.

Furthermore, we have recently discovered that the synthesis of lipids required for dendrite tree elaboration is cell - autonomously carried out and regulated by the neurons.

It's actually a very important transcription factor that's regulated by insulin, and this is involved in activating genes involved in fatty acid synthesis and so - called lipogenesis, which is synthesizing new lipids and this is, therefore, important in lipid metabolism.

Currently, Wang said her work is focused on two such metabolite - directed communication systems that regulate metabolic health and longevity: lysosome - to - nucleus retrograde lipid signals and microbe - to - host metabolite messages.

Others regulate food intake and lipid metabolism (e.g. leptin, chemerin).

This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.

Squats also regulate the body's lipid production that helps improve your cardiovascular functionality.