These findings suggest that ABL kinases
regulate osteoclast maturation indirectly, possibly by modulating osteoblast function.
Not exact matches
But I don't think that there's any pituitary atrophy that takes place once you stop taking endogenous HGH so
osteoclast activity should just stay being
regulated by PTH and Estrogen levels.
In a study exploring the molecules controlling
osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that
regulate gene expression) whose levels were consistently down - or up -
regulated in differentiating
osteoclasts.
Martin Sztacho (Hoflack, TUD)-- «F - BAR proteins PSTPIP1 and PSTPIP2
regulate sealing zones in bone resorbing
osteoclasts» (2014)
To evaluate whether ABL kinases might
regulate the secretion of osteoblast - derived RANKL or OPG leading to
osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.
To directly examine whether ABL kinases
regulate tumor - induced
osteoclast activation, we used an in vitro osteoclastogenesis assay (Fig. 5A).
Zinc
regulates secreting the bone - supporting hormone calcitonin, while copper monitors osteoblasts and
osteoclasts.