Sentences with phrase «regulate signaling in the brain»

The gaps help to regulate signaling in the brain, and the bridges are the «connection across a synapse [that] is the release key that fits into a very specific lock to initiate the next step.»

Not exact matches

A number of individual genes have been linked to suicide, such as those involved in the brain's response to mood - lifting serotonin, and a signalling molecule called brain - derived neurotrophic factor (BDNF), which regulates the brain's response to stress.

Latest research from the National Centre for Biological Sciences (NCBS, Bangalore), now shows that maintaining Calcium balance in cells is also needed for another purpose — it may be regulating the levels of an important signalling molecule called dopamine in the brain.

What was especially «exciting» about this finding, he says, is that these variations were near a neural highway that previous studies have shown helps regulate life span in worms and flies, and that stopping chemical signals from this brain pathway extends the life span of mice.

It was originally investigated in 1995 by pharmacologist Franco Borsini and a team of researchers at Boehringer Ingelheim Italia in Milan as an antidepressant because of its ability to regulate neurotransmitters — the brain's chemical - signaling molecules.

These include a family of signaling molecules called protocaderins, which regulate neuronal development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in brain development.

In a study being published in the journal Neuron, researchers show that the signal molecule TGF - beta acts as a time signal that regulates the nerve stem cells» potential at different stages of the brain's development — knowledge that may be significant for future pharmaceutical developmenIn a study being published in the journal Neuron, researchers show that the signal molecule TGF - beta acts as a time signal that regulates the nerve stem cells» potential at different stages of the brain's development — knowledge that may be significant for future pharmaceutical developmenin the journal Neuron, researchers show that the signal molecule TGF - beta acts as a time signal that regulates the nerve stem cells» potential at different stages of the brain's development — knowledge that may be significant for future pharmaceutical development.

UCLA researchers looked at levels of these neurotransmitters — glutamate and gamma - aminobutyric acid, known as GABA — in a brain region called the insula, which integrates signals from higher brain regions to regulate emotion, thinking and physical functions such as blood pressure and perspiration.

A neurosurgical procedure in which an implanted neurostimulator delivers electrical signals to specific areas of the brain to help regulate abnormal signals, DBS is currently only approved in the U.S. for the treatment of Parkinson's disease and essential tremor.

The resulting rhythmic signals produced by this transfer of cations are what support the synchronous contraction of our heart muscles and neuronal firing in parts of the brain, like the thalamus, which helps regulate our sleep - wake cycle, or circadian rhythm.

BREATHLESS Nerve endings in the lungs send signals — triggered by force - detecting proteins — to the brain and spinal cord that help regulate breathing.

For example, the scientists identified a deletion in one gene called «stargazin» that is required for regulating the transmission of signals between neurons in the brain.

When the researchers looked at brain size, they found that for fighters who had increasing levels of tau over time, there was a 7 percent decline in the volume of their thalamus, which is located in the center of the brain and regulates sleep, consciousness, alertness, cognitive function and language while also sending sensory and movement signals to other portions of the brain.

January 4, 2006 Chemical signaling helps regulate sensory map formation in the brain Researchers from the University of Chicago have uncovered an important mechanism used by the developing brain to pattern nerve connections in the part of the brain that interprets visual signals.

Corollary studies focused on the mechanisms that regulate brain endocannabinoid signaling have provided critical in vivo evidence of an «on demand,» activity - dependent nature of endocannabinoid influence.

In humans, low levels of hydrogen sulfide serve as a signaling molecule that helps regulate physiological processes in the brain, heart and other organIn humans, low levels of hydrogen sulfide serve as a signaling molecule that helps regulate physiological processes in the brain, heart and other organin the brain, heart and other organs.

In the new study, Song and colleagues discovered that this hippocampal PV interneuron - signaling is regulated by a GABA circuit coming from the medial septum, a cluster of neurons near the front of the brain.

In terms of pathogenic mechanisms of PD, given that miR - 181a is selectively up - regulated in nigrostriatal DA neurons of the PD brain [13], our current findings suggest that this up - regulation in miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivIn terms of pathogenic mechanisms of PD, given that miR - 181a is selectively up - regulated in nigrostriatal DA neurons of the PD brain [13], our current findings suggest that this up - regulation in miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivin nigrostriatal DA neurons of the PD brain [13], our current findings suggest that this up - regulation in miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivin miR - 181a may contribute to the ongoing mDA axonal degeneration by inhibiting BMP - Smad signalling in vivin vivo.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Researchers have found a new group of cells in the retina that directly affect the biological clock by sending signals to a region of the brain which regulates our daily (circadian) rhythms.

Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling.

This signaling helps the brain regulate certain hormones in the body that are responsible for waking us up and helping us fall asleep at night.