Sentences with phrase «regulated by infection»

By sequencing RNA from infected and uninfected control samples and identifying genes that are differentially regulated by infection status, it is possible for the first time to identify all genes regulated by a specific immune challenge independent of homology - based annotations.

To identify genes that are regulated by infection, we used the DESeq2 package [48] in Bioconductor / R.

Of the remaining 14,150 genes which could be analyzed for differential expression, 1.29 % are up - regulated by infection and 0.43 % are down - regulated by infection.

Using a negative binomial approach implemented in the R / Bioconductor package DESeq2 [48], we identify 183 genes significantly up - regulated by infection at a 10 % FDR, and 61 genes significantly down - regulated by infection at a 10 % FDR (Figure 1; Table S2).

Here, we use RNA - seq to compare the uninfected and infection - induced transcriptome in the parasitoid wasp Nasonia vitripennis to identify genes regulated by infection.

The advent of RNA - seq technology, in conjunction with full genome sequencing, provides a method for the unbiased characterization of genes regulated by infection in almost any species that can be manipulated in the laboratory.

Not exact matches

Nibbering and a team of Dutch collaborators are trying to combat these biofilm - associated infections by improving on a human peptide called LL - 37, which helps regulate the body's immune response.

The brain is protected by a barrier of cells that tightly regulates the transport of substances into this organ in order to prevent infection.

Not only is RNAi used to regulate gene expression within an organism, it also can combat viral infection by silencing the activity of viral genes required for the pathogen's replication.

Through mapping proteins that can restrict viral infections, the researchers found a protein called YTHDF2 that can help regulate the human herpes virus 8 by detecting the m6A modification on viral messenger RNA.

«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).

Systemic bacterial infections such as those caused by Salmonella are highly regulated and complex processes that include sophisticated offensive and defensive strategies by both pathogen and host that are orchestrated by virulence factors.

They theorized that in people who were genetically susceptible, an accidental assault by cells normally tasked with fighting infection destroyed neurons crucial for regulating sleep.

While not all genes with an immune function will necessarily be regulated by any specific infection, and thus an RNA - seq - based catalog of immune - related genes can not be expected to be complete, it has the significant advantage of being unbiased by assumptions about conservation of genes across species, and thus serves as a valuable starting point for comparative analysis of the evolution of immune pathways.

As expected, the 497 immune genes we describe above by homology are significantly over-represented among induced genes: 5.6 % of immune genes with detectable expression are up - regulated after infection, compared to 1.2 % of non-immune genes (Fisher's Exact Test, P = 2.735 × 10 − 11).

Omega - 3s play a role in immune function by regulating inflammation and encouraging the body to fight infection.

These crucial gut organisms help us digest food, produce chemicals and substances within the body, control infections by pathogens, regulate the immune system, and even control emotions.

Cortisol prepares the body to combat stress from illness, trauma, fright or infection by regulating blood sugar levels and immune responses.

Another terpene, α - pinene is released by plants as a volatile defense mechanism, yet seems to decrease inflammation by inhibiting NF - κB (Nuclear Factor Kappa B).11 NF - κB regulates our immune response and is turned on in response to harmful states like infection.

It also appears that some of the downstream products of Arachidonic Acid - prostaglandin E2 and thromboxane B2, both produced under the COX pathway - can actually up - regulate infections by some pathogens, i.e. C. albicans:

«The lymphatic system has a vital role in the body by regulating the immune system, which protects the body against infection.

Lavender oil restrains bacteria that causes the initial infections, manipulates hormones by regulating amount of sebum being released, and can minimize scarring left from acne.

Many health claims are made for cinnamon including helping to regulate blood sugar and fighting infections caused by fungi (such as Candida albicans or yeast) or bacterial (such as E. coli).

However, one of the major proposed mechanisms to account for the relationship between prenatal psychosocial stress and the offspring's susceptibility to infections is the secretion of cortisol, which is regulated by the maternal HPA axis and the placenta [14,20].