Further, it would suggest that sex - specific morphology can evolve by spatially
regulated changes in expression within the sex - determining pathway without disrupting other sex - determination functions.
Not exact matches
The researchers found that the blond hair commonly seen
in Northern Europeans is caused by a single
change in the DNA that
regulates the
expression of a gene that encodes a protein called KITLG, also known as stem cell factor.
The researchers linked the excess weight and
changes in metabolism to epigenetic modifications that reduce
expression of the gene for adiponectin — a hormone that helps
regulate several metabolic processes, including glucose regulation.
Further analysis revealed that overexpression of these lncRNAs
in turn
changed the
expression of proteins that
regulate a well - known developmental process, termed the epithelial - to - mesenchymal transition (EMT).
Analysis showed that incremental
changes in the number of repeats caused non-harmful variations
in the
expression of the genes
regulated by Ssn6.
The researchers discovered that the Activin pathway controls the ability of cocaine to induce this
change in the neurons and determined that the Activin receptor may control this response to cocaine by
regulating the
expression of a number of genes.
«Understanding which genes are involved
in transgenerational acclimation, and how their
expression is
regulated, will improve our understanding of adaptive responses to rapid environmental
change and help identify which species are most at risk from climate
change and which species are more tolerant,» Dr Veilleux says.
Using this «Ribotag» approach tissue - specific
changes under DR have been measured
in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene
expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially
regulated genes.
Thus, interactome hubs such as NR1 may exhibit low levels of
change in individual gene
expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role
in regulating the biologic response.
Evaluating
changes in gene
expression patterns of Kif5b and Psmd6: Are they
regulated by GOLGA3?
Nick Owens, a post doc
in Mike Gilchrist's lab, who developed the computational analysis, said: «This study improves our ability to understand the way gene
expression changes with time, and from this we gain insight into the logic of how gene
expression is
regulated.
Using novel gene - array technology to measure the extent of gene
expression in thousands of genes simultaneously, this study shows that as humans diverged from their ape ancestors
in the last five million years, genes for transcription factors — which control the
expression of other genes — were four times as likely to have
changed their own
expression patterns as the genes they
regulate.
Panne wonders if that pivotal moment on Earth may have gone hand
in hand with the unique merge function of transcription factors and a dramatically
changed ability to
regulate genome
expression.