Sentences with phrase «regulated kinase»

Abbreviations: AMPAR, AMPA receptor; AS, Angelman syndrome; BDNF, brain - derived neurotrophic factor; CaMKII, α - calcium / calmodulin - dependent protein kinase II; CGN, cerebellar granule neuron; co-IP, coimmunoprecipitation; DG, dentate gyrus; ERK, extracellular signal - regulated kinase; fEPSP, field excitatory postsynaptic potential; Gab1, Grb2 - associated binder 1; HFS, high frequency stimulation; IGF, insulin - like growth factor; LTP, long - term potentiation; PSD - 95, postsynaptic density protein - 95; SYN, synaptophysin; WT, wild type

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Moreover, these ATP - competitive inhibitors induce the formation of B - RAF and C - RAF dimers, leading to extracellular signal — regulated kinase (ERK) activation in diverse cancer cell types (23).

Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen - Activated Protein Kinase / Extracellular Signal — Regulated Kinase Activity

Anastellin, a fragment of the first type III repeat of fibronectin, inhibits extracellular signal - regulated kinase and causes G1 arrest in human microvessel endothelial cells.

Rho family GTPase inhibition reveals opposing effects of mitogen - activated protein kinase kinase / extracellular signal - regulated kinase and Janus kinase / signal transducer and activator of transcription signaling cascades on neuronal survival.

Activity assays for extracellular signal - regulated kinase 5.

Extracellular signal - regulated kinase promotes Rho - dependent focal adhesion formation by suppressing p190A RhoGAP.

Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53 - independent but extracellular signal - regulated kinase - p38 mitogen - activated protein kinase - dependent mechanism.

Caveolin - 1 is required for kinase suppressor of Ras 1 (KSR1)- mediated extracellular signal - regulated kinase 1/2 activation, H - Rasv12 - induced senescence, and transformation.

Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal - regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action.

Duration and strength of extracellular signal - regulated kinase signals are altered during positive versus negative thymocyte selection.

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).

Regulation of α2B - Adrenergic Receptor - mediated Extracellular Signal - regulated Kinase 1/2 (ERK1 / 2) Activation by ADP - ribosylation Factor 1.

Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2.

Based on the current study results, the team believes a particular enzyme, «dual specificity tyrosine - regulated kinase - 1a (DYRK1A),» is the likely target of harmine.

Thioredoxin - 1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the regulation of apoptosis through the inhibition of apoptosis signal - regulating kinase - 1 (Ask - 1).

Not exact matches

The protein, tyrosine kinase 2 or TYK2, helps regulate how strongly the immune system responds to threats.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

The scientists propose that Src42A — a protein that belongs to the family of kinases that regulates the structure of the actin filament — is one of the main contributors to this system.

But major pharmaceutical laboratories are investigating highly selective inhibitors of this molecular linchpin, many of them targeted at the enzymes (such as I - kB kinase) that regulate NF - kB activity.

These proteins, which are controlled by the metabolic sensor AMP - activated protein kinase, regulate fat production as well as the ability to burn fat.

Then, the research group examined the molecular mechanism behind the impaired synaptic functions and behaviors in ARHGAP33 KO mice and found that ARHGAP33 is localized to the Golgi apparatus to regulate intracellular protein trafficking of the Tropomyosin receptor kinase B (TrkB) receptor, a neurotrophin receptor, to synaptic sites.

For example, Capsaspora activated transcription factors and a tyrosine - kinase signaling system in different stages to regulate protein formation.

In addition, the research team discovered that the development of ILT3 in Treg cells is regulated by protein kinase CK2.

Protein kinases, most scientists would agree, regulate nearly every aspect of cell life.

«If we find a kinase that regulates filopodial bridge formation or a kinase that facilitates virus surfing along a filopodium,» he says, these enzymes can be targeted to thwart infection.

Some of its members have similar structures, which has led some researchers to propose that the activity of these kinases is probably regulated in a similar manner and, therefore, may be targeted with similar medications.

Most cells do not divide until they reach a size characteristic of each cell type, and Thomas and his colleagues suspect that S6 kinase helps to regulate that signal.

«Our study delineates an lncRNA - protein kinase module that regulates HIF1,» said Yang.

Teesalu et al., Salt - Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH / NADP + Redox Balance, Current Biology (2016), http://dx.doi.org/10.1016/j.cub.2016.12.032

Emk is a serine / threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics.

Tyrosine kinases may regulate choanoflagellate colony formation.

Berg, L.J. Signalling through TEC kinases regulates conventional versus innate CD8 + T - cell development.

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).

MicroRNA -7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3 - kinase / Akt signalling pathway.

Protein kinase C regulates AMPA receptor auxiliary protein Shisa9 / CKAMP44 through interactions with neuronal scaffold PICK1.

Interestingly, this anti-apoptotic function of ADAR1 is regulated through its phosphorylation by MAP kinases.

Two proteins that serve as critical inhibitory regulators downstream of the TCR are diacylglycerol kinase ζ (DGKζ), a regulator of Ras and PKC - θ signaling, and Casitas b - lineage proto - oncogene b (Cbl - b), an E3 ubiquitin ligase that predominantly regulates PI (3) K signaling.

Cortical F - actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine - rich C - kinase substrate and myosin II.

The c - Abl tyrosine kinase regulates actin remodeling at the immune synapse.

Moreover; it has been observed that elevated calcium levels and interaction of the membrane bound DAG with protein kinase C (PKC), activates PKC's kinase activity, which is known to regulate the cellular activity of MAPK [41].

Cyclin - dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Virus binding to cognate receptors also can regulate phosphoinositide kinases.

Hematopoietic Lineage Cell - Specific Protein 1 Is Recruited to the Immunological Synapse by IL -2-Inducible T Cell Kinase and Regulates Phospholipase Cγ1 Microcluster Dynamics during T Cell Spreading.

p210 BCR / ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.

The Plasma Membrane - Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C - Regulated Dopamine Transporter Trafficking.

Trauma - induced expression of astrocytic thrombospondin - 1 is regulated by P2 receptors coupled to protein kinase cascades.

Protein kinase Cα and ζ differentially regulate death - inducing signaling complex formation in cigarette smoke extract - induced apoptosis.

Integrin - linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.