A tissue culture study of human breast - cancer cells found that epigallocatechin gallate, or EGCG, an active compound in green tea, protects against some forms of breast cancer by
regulating estrogen receptors on breast cells and inhibiting growth and reproduction of estrogen - dependant breast - cancer cells.
Not exact matches
Of these genes, nearly half that were being suppressed were
regulated by
estrogen receptor alpha (ESR1), and their down - regulation was noted by the 30 minute mark.
GT198, which is also a coactivator of
receptors for steroid hormones such as
estrogen, is normally
regulated by
estrogen, Ko said.
Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal - regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen
Estrogen receptor protein interaction with phosphatidylinositol 3 - kinase leads to activation of phosphorylated Akt and extracellular signal -
regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of
estrogenestrogen action.
Not only is the progesterone
receptor an «essential modulator of
estrogen -
receptor -
regulated genes,» but it also significantly contributes to the «prognostic value of
estrogen receptors in ER + / PR + breast cancers.»
Moreover,
estrogen can exert direct effects on fat tissue by enhancing proliferation of preadipocytes, especially in females (232), and by up -
regulating sc α2A - adrenergic
receptors promoting SAT accumulation, notably in premenopausal women (233).
This
receptor interacts with nerve fibers that
regulate the release of
estrogen.
In vivo, breast cancer growth is
regulated by
estrogens and peptide growth factors, such as epidermal growth factor (EGF), the
receptor of which has intrinsic PTK activity.
Dr. Lindsey Berkson: For example, like melatonin, we'll get a woman who just had breast cancer on high dose melatonin because it down
regulates estrogen alpha
receptors so that your... In fact, if you give a very high dose of melatonin to a young menstruating woman, you can get her to stop menstruating because it turns off
estrogen so powerfully.
Insulin
regulates how much
estrogen is available to attach to the
receptors.