Sentences with phrase «regulates genes controlling»

For the first time, researchers have identified a long non-coding ribonucleic acid (ncRNA) that regulates genes controlling the ability of heart cells to undergo repair or regeneration.

Not exact matches

Cells have more than one trick up their sleeve for controlling certain genes that regulate fetal growth and development.

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

«Our study provides compelling evidence that the fetus regulates the timing of its birth, and that this control occurs after these two gene regulatory proteins − SRC - 1 and SRC - 2 − increase the production of surfactant components, surfactant protein A and platelet activating factor,» said senior author Dr. Carole Mendelson, Professor of Biochemistry, and Obstetrics and Gynecology at UT Southwestern.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

To explore these questions Akiko Iwasaki, professor of immunobiology and investigator of the Howard Hughes Medical Institute, and her co-authors observed replication of the Zika virus in the vaginal tissue of control, wild - type mice (genetically unmodified mice) and mice lacking genes that regulate immune system proteins known as type I interferons.

Further study revealed that UPB1 regulates the expression of three genes, called peroxidases, which themselves control the distribution of two chemicals, hydrogen peroxide and superoxide, in the root.

Given its critical role in controlling gene expression, SETDB1 must be precisely regulated to ensure that molecular processes run properly.

The initial hint that KLF4 regulates mitochondrial biology came from genome - wide studies that revealed a strong signature for KLF4's control of mitochondrial genes.

So Hoffman is now looking for leads among genes controlling the production of molecules called growth factors, which regulate cell growth and division.

The researchers discovered that the Activin pathway controls the ability of cocaine to induce this change in the neurons and determined that the Activin receptor may control this response to cocaine by regulating the expression of a number of genes.

Two other genes that the analysis suggested had evolved in the Bajau were BDKRB2, which controls blood vessel constriction in the extremities, and FAM178B, which helps regulate carbon dioxide balance in the blood.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

Chromatin is the protein packaging that helps regulate genome function by controlling access to DNA; changes in this packaging can affect gene regulation.

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

RNA is a fundamental molecule that codes for protein and controls gene expression, playing a part in regulating many cell responses and vital processes.

Researchers observed that the set of genes involved in memory consolidation coincided with the genes regulating Crtc1, a protein which also controls genes related to the metabolism of glucose and to cancer.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

The findings are especially important as they highlight the discovery of a regulatory sequence, termed the J element, that controls class I gene expression of many more genes than the counterparts that regulate class II gene expression.

The Center for RNA Research at the Institute for Basic Science has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.

CREs are regions of genome DNA that do not code for proteins, and control morphology and other traits by regulating genes.

As is clear from the examples above, it is critical that the production levels of size - regulating genes such as dpp, tkv, and dally be precisely controlled.

Acetylation — the addition of a small clump of atoms called an acetyl group — may be the most important body process you have never heard of: It activates and deactivates proteins, thereby regulating access to our DNA and helping control gene expression.

These sequences in our DNA are often situated far away from the actual genes they regulate, in comparison to so called promoter regions, which traditionally have been considered to control most of the gene activity.

The FT1 gene was known to regulate the transition to flowering and FT2 is important for controlling fall growth cessation and bud set.

Despite having tightly controlled expression levels, little is known about how miRNAs themselves are regulated because their genes are poorly defined.

In order to control the several genes that are regulated by the flagellum activity and by quorum sensing, we first deleted flaA, which encodes the flagelling core protein, and hapR, which encodes the quorum sensing master regulator.

University of Lisbon: Professor Margarida Gama Carvalho («Characterization of post-transcriptional control mechanisms regulating SMN2 gene expression.»)

We report evidence for spatiotemporal control of a BR biosynthesis gene in regulating meristem fate to pattern inflorescence form.

Genes that regulate aspects of growth and the control of acidity appeared most affected.

Specifically, they analyzed the tumors» epigenome, an array of molecules that covers the surface of DNA and helps regulate gene activity, acting like a control switch to decide which genes are active or inactive in the cell.

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

Endowed with the power to control the activity of other genes, GTF2I might regulate signal pathways determining the structure and function of the brain or the production of neurohormones such as vasopressin and oxytoxin.

They identified genetic mechanism controlling this process in all three — a common set of miRNA - regulated genes that diverged on the evolutionary tree aproximately 420 million years ago.

«Because the Met - SRC complex regulates a gene that controls reproductive development in crustaceans, we know that such activity means there is a significant likelihood of environmental toxicity — enough to make it a priority for in - depth toxicity testing,» LeBlanc says.

These observations suggest that ARE - regulated genes may be controlled by an intracellular ligand independent of ROS generation, electrophilic reactivity or elevation of Nrf2 levels in the cell.

Using novel gene - array technology to measure the extent of gene expression in thousands of genes simultaneously, this study shows that as humans diverged from their ape ancestors in the last five million years, genes for transcription factors — which control the expression of other genes — were four times as likely to have changed their own expression patterns as the genes they regulate.

Traditional small molecules targeting ARE - regulated gene activation (e.g., bardoxolone, dimethyl fumarate) function by alkylating numerous proteins including Keap1, the controlling protein of Nrf2.

There is, however, another mechanism by which ARE - regulated genes are controlled and that is through Bach1, a transcriptional repressor that binds to ARE promoter elements resulting in suppression of Nrf2 activity.

Dr. Loftus» research is aimed at understanding how the human genome regulates gene expression, with a focus on how this controls the cellular processes governing mammalian development.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

By sequencing RNA from infected and uninfected control samples and identifying genes that are differentially regulated by infection status, it is possible for the first time to identify all genes regulated by a specific immune challenge independent of homology - based annotations.

This study seeks to identify all the genes throughout fruit development, different tissue types, DNA that regulates those genes, hormones and their control, and the structural polymers that make up cells walls and contribute to fruit texture, and the ability to resist drying out.

The investigators profiled the expression of microRNAs (miRNAs), which regulate gene expression, in aqueous humor samples from patients with POAG, XFG and cataracts (non-glaucoma controls).

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.

Marker Predicts Aggressive Prostate Cancer Prostate cancer researchers identified a group of genes that regulates and controls normal prostate development.

While the role that DNA - binding proteins play in regulating gene expression at the transcriptional level is well studied, how RNA - binding proteins control gene expression at the post-transcriptional level is less clear.