Sentences with phrase «regulates protein synthesis»

mTORC1 is the central component of the insulin - signaling cascade [insulin / insulin - like growth factor (IGF)-- phosphatidylinositol 3 - kinase (PI3K) pathway)(Fig. 1) that regulates protein synthesis and mRNA translation through 2 primary mechanisms: 1) inactivation of the repressor of mRNA translation, eukaryotic translation initiation factor 4E - binding protein 1 (eIF4E - BP1), and 2) the activation of 70 - kDa ribosomal protein S6 kinase.

mTOR is a biochemical pathway that regulates protein synthesis.

«Moreover, they offer a potential approach to treating individuals with Fragile X syndrome: targeting a specific protein, eIF4E, that regulates protein synthesis.»

Previous studies have shown that eIF4E plays a key role in regulating protein synthesis in the brain.

Joe's early implementation of molecular techniques to study auxin - regulated gene transcription and heat shock — regulated protein synthesis laid a foundation for the field of plant molecular biology.

Research into the fundamental processes that regulate protein synthesis and folding within the ER should have impact on the understanding of genetic diseases that result from protein folding defects.

Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42

MiRNAs regulate protein synthesis in the cell cytoplasm by promoting target mRNAs» degradation and / or inhibiting their translation.

Recent studies demonstrate that NO - synthase participates in the regulation of protein and energy metabolism in skeletal muscle by fine - tuning and stabilizing complex signaling systems which regulate protein synthesis and degradation.

The remainder of this review focuses on recent studies assessing the molecular mechanisms regulating protein synthesis and breakdown and the potential influence of amino acids as signaling molecules.

Not exact matches

Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA, RNA and protein synthesis and learning how these interactions are regulated.

They further theorized that an inhibitory feedback loop of the PER protein blocks the activity of the period gene, so the protein could prevent its own synthesis and thus regulate its own levels in a constant rhythm.

In this pathway, dopamine - and an adenosine 3 ′, 5 ′ - monophosphate (cAMP)-- regulated phospho - protein of 32 kilodaltons (DARPP - 32) is phosphorylated or dephosphorylated at three sites, in a pattern predicted to cause a synergistic inhibition of protein phosphatase — 1 and concomitant regulation of its downstream effector proteins glycogen synthesis kinase — 3 (GSK - 3), cAMP response element — binding protein (CREB), and c - Fos.

In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one of the daughter cells.

Instead, he and colleagues focused on a different role for FMRP — regulating the synthesis of proteins that alter DNA packaging.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

Although research into protein degradation has lagged behind research into protein synthesis, it is now well appreciated that when it comes to proteins, death is just as important as birth — and as tightly regulated.

This causes eIF4E to instead bind to CYFIP1, which reduces protein synthesis as well as a pathway that regulates actin dynamics.

Together, these observations demonstrate that blood - forming stem cells require a highly regulated rate of protein synthesis, such that increases or decreases in that rate impair stem cell function.

Her research also has highlighted a central role for the localization of RNAs to synapses, where their synthesis into protein is regulated by neuronal activity, and that the process of local protein synthesis is likely to play a particularly important role in autism spectrum disorders.

So, as you can see, this insulin signaling cascade, at least on this arm, regulates a number of aspects of metabolism; both carbohydrate and synthesis carbohydrate metabolism, as well as protein synthesis and metabolism.

DG031 is designed to inhibit the FLAP, or 5 - lipoxygenase activating protein, which regulates the synthesis of leukotrienes.

Anna Vorobyeva is characterizing human autism - associated single nucleotide variants (SNVs) in genes encoding proteins that regulate global protein synthesis.

This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.

Synthesis of pathogenesis - related proteins in tobacco is regulated at the level of mRNA accumulation and occurs on membrane - bound polysomes

eFFECTOR is pioneering a new class of small molecule drugs that act by selectively regulating translation, also known as protein synthesis.

More specifically, growth hormone increases protein synthesis and cell transport, regulate metabolism, and remodel bone and collagen tissues.

An essential mineral that boosts immune system, balances the hormones in the body, plays a role in protein synthesis, and regulates blood sugar levels.

These minerals play a key role in your health and regulate diverse biochemical reactions, from nerve and muscle function and protein synthesis.

It plays a key role in protein synthesis and regulates the ammonia levels in your body.

Growth hormone, an anabolic hormone sometimes called your fountain - of - youth hormone because it keeps you lean and toned, plays a major role in regulating muscle growth and development, stimulating muscle protein synthesis.

Rats fed protein - deficient diets have decreased DBP concentrations and a decreased ability to regulate calcium metabolism.38 Humans with acute liver failure also have depressed levels of DBP.39 This may be because the synthesis of DBP in the liver declines during such a condition, but DBP also plays a secondary role in scavenging harmful cellular debris from the blood; therefore, any kind of acute tissue damage can overwhelm our supply of DBP.

It also helps the liver to process toxins, helps with DNA and protein synthesis, and regulates both the nitric oxide cycle and the metabolism of iron.

It plays a role in metabolism, regulates pH balance, assists with protein synthesis and helps with the digestion of carbohydrates.

Although insulin will help to shuttle amino acids into cells, the availability of leucine is shown to be far more important in regulating pathways of protein synthesis [vii].

Selenium rich protein foods help regulate hormone synthesis and the conversion of inactive hormones to active ones.

It helps maintain normal muscle and nerve function, keeps the heart rhythm steady, supports a healthy immune system, keeps bones strong, regulate blood sugar levels, promotes normal blood pressure, and is involved in energy metabolism and protein synthesis.

Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise.

And then there's all these fancy terms that are being thrown around — «carb cycling», «muscle protein synthesis», regulating my auto, wut?

So leucine not only provides the building blocks for protein synthesis, it also plays a critical role in up - regulating the process.

Animal and clinical studies indicate that the AR signaling pathway is required for appropriate development of skeletal muscles, since it regulates increases in lean muscle mass, muscle strength, and muscle protein synthesis.

Zinc, being an important mineral, plays a vital role in protein synthesis and helps regulate the cell production in the immune system of the human body.

AMP - activated protein kinase suppresses protein synthesis in rat skeletal muscle through down - regulated mammalian target of rapamycin (mTOR) signaling

Decreased mTORC1 activation and subsequent decreases in muscle protein synthesis, coupled with increased FOXO nuclear localization, increased transcription of atrophy - related genes, with up - regulated caspase 3 activation and muscle protein ubiquitylation provide a possible mechanism contributing to skeletal muscle loss in response to periods of negative energy balance.

These particular amino acids are key in stimulating protein synthesis and regulating protein metabolism.

In response to negative energy balance, mRNA translation and muscle protein synthesis may be down - regulated as a result of decreased nutrient and growth factor availability, causing reduced mTORC1 activation.

Gene therapy is aimed at regulating the genes and their specific protein synthesis.