Sentences with phrase «regulating cell cycle»

Why It Matters: In human cells, signaling (i.e. telling the cell what to do such as releasing hormones or regulating a cell cycle) is initiated by external cues, and cell receptors facilitate the relay of the received information to regulatory elements in the cell.

Stathmin is essential for the regulation of the cell cytoskeleton, which is required for numerous cell processes including regulating the cell cycle, cytoplasmic organization, cell division and cell motility...

In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one of the daughter cells.

The closest relative of NDT80 in mammals is p53, a gene that regulates cell cycles.

For example, genes in the CDK family regulate the cell cycle and are commonly mutated or deleted in many cancers.

Proteasomes play an important role in the degradation of proteins that regulate the cell cycle, thereby regulating cell growth.

When expressed normally, the protein acts as an enzyme at the cell membrane, instigating a complex biochemical reaction that regulates the cell cycle and prevents cells from growing or dividing in an unregulated fashion.

The A. queenslandica genome allows us to assess systematically the origin of the six hallmarks of metazoan multicellularity: (1) regulated cell cycling and growth; (2) programmed cell death; (3) cell — cell and cell — matrix adhesion; (4) developmental signalling and gene regulation; (5) allorecognition and innate immunity; and (6) specialization of cell types.

Not exact matches

But because genes can regulate multiple processes, more work is needed to determine the safety of modifying the cell cycle in such a way.

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the cell - cycle regulated HO gene in the yeast Saccharomyces cerevisiae.

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

«This evidence suggests that the DNA timing mechanism is highly conserved, and it is possible that other time - critical functions related to the cell cycle may be regulated in a similar way.

This is the first demonstration of TBK1 regulating mitosis and cell cycle progression.

Cells go through a highly regulated, ordered process to divide and multiply, called the cell cycle.

This complex is involved in regulating the cell replication cycle, which becomes dysregulated in cancer.

Lee's study results, which appear in the July 16, 2015 issue of Nature Communications, revealed new understanding about how 14 -3-3 sigma — a cell cycle «controller» - regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor - producing factories.

CDKs regulate a series of events known as the cell cycle, or cell - division cycle, that lead to the division and duplication of cells.

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

In contrast to necrosis, which is a form of cell death that results from acute tissue injury and provokes an inflammatory response, PCD is carried out in a regulated process that generally confers advantages during an organism's life cycle.

«In modern biology mitochondria are considered to be much more than the powerhouse of the cell; they integrate multiple intracellular signals to regulate progression through the cell cycle and into apoptosis.

Patients lose certain brain cells in the hypothalamus, leading to a deficiency of hypocretin, a molecule that helps regulate the sleep - wake cycle.

The predicted hosts for the Klosneuviruses are protists (single - celled eukaryotic (nucleus - containing) microorganisms) and while their direct impacts on protists are not yet worked out, these giant viruses are thought to have a large impact on these protists that help regulate the planet's biogeochemical cycles.

Emk is a serine / threonine protein kinase implicated in regulating polarity, cell cycle progression, and microtubule dynamics.

Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2.

Proteasomal activity must be precisely regulated to direct cells through cell division, degrading the right proteins at the right time to help the cell progress to the next step in the division cycle.

The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell - cycle gene and protein expression.

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Anil Belur Nagaraj (Bornhäuser, TUD)-- «Understanding the regulation of tumor cell cycle to identify and characterize factors that negatively regulate the tumor phenotype.»

The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell - cycle phosphorylation.

Moreover, the Galli group studies cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology and in disease.

To address the mechanism of growth inhibition by DDX3, we examined whether the promoter activity and the expression level of the cell cycle regulator p21waf1 / cip1 are regulated by DDX3.

His group also studies two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle, and that BRCA1 regulates gene activity.

Immunohistochemical demonstration of Cyclin D1 have become an important mean for assessing cell proliferation, therefore the immunohistological demonstration of cell cycle related antigens such as CDKs which regulated by the different cyclins could provide a good tool for assessment of cellular proliferation [11].

Dr. Verma's group is also studying two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle and that BRCA1 regulates gene activity.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

CPEB (Cytoplasmic Polyadenylation Element Binding) proteins are a family of four RNA - binding proteins that regulate the translation of maternal mRNAs controlling meiotic cell cycle progression.

In all living organisms, the cell cycle must be tightly regulated to ensure that new cells are created only when necessary and have an accurate copy of DNA to function normally.

These three CPEBs have sequential non-redundant functions that promote the phase - specific polyadenylation and translational activation of CPE - regulated transcripts in the mitotic cell cycle.

In response to DNA damage, the checkpoint regulates and coordinates many cellular processes critical for genomic stability, including cell cycle progression, DNA repair, DNA replication, and apoptosis.

BSI member and senior author, Dr Martin Turner, said, «Our findings shed light on the intricate control and coordination of the cell cycle and show that these binding proteins probably form part of a common mechanism to regulate quiescence, not just one specific to developing B cells.»

«Even though we identified 81 percent of the genes that were already known to be cell - cycle regulated, we found only about a 65 percent overlap between cell - cycle genes identified by our method and the previous method.

Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.

Breeden anticipates using this method to identify coordinately regulated cell - cycle genes and ultimately elucidating the mechanisms that control their gene expression.

In the 1990s, researchers were beginning to understand the ways cells regulate transitions into the four phases of the cell cycle: G1, synthesis (S) phase, G2, and mitosis.

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

These commonly regulated genes clustered into the functional category of cell - cycle regulators.

Leptin is a hormone that directly regulates both hunger cycles and the amount of fat cells in the bloodstream.