«It suggests to us that targeting the pathways used in
regulating cell fate decisions — how stem cells choose between cell proliferation and differentiation — could be a more effective way of halting tumours in their tracks and lead to potential new therapies.»
A two - step process appears to
regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.
Not exact matches
«What changes a
cell, or what
regulates a
cell to follow certain
cell fate decisions?
Specifically, we investigate the molecular events
regulating developmental
decisions that instruct cardiac progenitor
cells to adopt a cardiac
cell fate and subsequently fashion a functioning heart.
Found that muscle - specific histone methyltransferases and microRNAs
regulate the activity of Hand2, a transcription factor essential for ventricle formation and more recently showed that microRNAs can efficiently guide stem
cell fate decisions.
Specifically, we study the molecular events
regulating early and late developmental
decisions that instruct progenitor
cells to adopt a cardiac
cell fate and subsequently fashion a functioning heart.
The lab will be focused on the identification of cellular and molecular events
regulating hematopoietic
cell fate decisions with emphasis on DC development.