Sentences with phrase «regulating cell growth»

mTOR is a biological pathway in the body which plays an important role in regulating cell growth and proliferation that may also have an influence over cancer growth (6).

Vitamin D - 3 also plays an important role in regulating cell growth, insulin levels, and bone formation.

It triggers the action of enzymes and is an important component of proteins responsible for regulating cell growth, reproduction and death.

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

Previously described as the «guardian of the genome» and voted «Molecule of the Year» in 1993, p53 is one of the most important proteins regulating cell growth and a major focus for oncology research.

Proteasomes play an important role in the degradation of proteins that regulate the cell cycle, thereby regulating cell growth.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

In cancer, these switches inappropriately activate or silence important genes, such as those that regulate cell growth and life cycle, ultimately leading to tumors.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

P53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.

So Hoffman is now looking for leads among genes controlling the production of molecules called growth factors, which regulate cell growth and division.

Jasper says researchers at the Buck are also testing homologues of rapamycin that are more specifically aimed at TOR Complex 1 — a key complex containing TOR that regulates cell growth and metabolism in all complex organisms.

The protein mTOR regulates cell growth and metabolism and thus plays a key role in the development of human disorders.

Most group 3 medulloblastoma tumors feature excessive levels of the c - MYC protein, which helps to regulate cell growth.

Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead to cancer.

As a result, they can more efficiently interact with the cell membrane, regulate cell growth and suppress tumor formation.

mTOR - raptor complex is sensitive to rapamycin and regulates cell growth, in part, by phosphorylation of p70S6K and subsequently rpS6 and 4E - BP1, thus promoting protein translation.

-- A fundamental question in biology is how multicellular organisms regulate their cell growth.

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.

The main function of growth hormone is to regulate cell growth and regeneration in all tissues, including muscles and bones.

The first trial will evaluate Rapamycin, also known as Sirolimus, a promising cancer treatment drug that targets a protein that regulates cell growth.

Not exact matches

Eicosonoids from Omega - 3's are hormone - like compounds that help regulate blood pressure, blood clotting, aid in growth and development of cells, needed for vision and brain development, and maturation of nerves.

Additionally, the vitamin helps regulate the immune system, cell growth, and insulin within your little one's body.

Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.

Cells have more than one trick up their sleeve for controlling certain genes that regulate fetal growth and development.

To get more cells, researchers from Advanced Cell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developmCell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific developmcell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific development.

A third influential gene was ARMS / KIDINS220, which codes for a protein that regulates the growth of nerve cells.

Higher amounts of insulin are more likely to cause cells to lose their ability to regulate growth, a precursor to cancer.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

A recent laboratory experiment at Boston University revealed that by activating the circulating form of the vitamin, prostate cells could regulate their own growth and possibly prevent the rise of cancer.

In this study, the scientists have examined how Dpp regulates growth and analysed how cells behave when Dpp levels are manipulated.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.

About ten years ago, research results showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

According to Beg, NF - κB proteins regulate key genes involved in immune response, inflammation, cell death and cell growth.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system.

AMPK responds to energy deficits in the cell by down - regulating energy consuming processes, which are often associated with cell growth, and up - regulating energy producing processes.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

IGFBP3, a direct KDM6A / EZH2 / H3K27me3 target, was up - regulated by EZH2 inhibition and contributed to the observed EZH2 - dependent growth suppression in KDM6A - null cell lines.

She notes that stem cells normally divide and reproduce in a very regulated way, «but these signals get hijacked during cancer formation and may promote cancer growth.»

PI3K is responsible for regulating the growth and survival of cancer cells and several inhibitors targeting it have already been developed.

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

The inhibition is regulated by different molecules in animals and plants,» explains NAIST Professor Masaaki Umeda, who studies the role of stem cells in plant growth.

Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for stem cell researchers in regards to cell size checkpoints and their importance during organism development.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.