Sentences with phrase «regulating lysosome»
Identification of mechanisms regulating lysosome homeostasis and their role in protecting neurons against aging
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Northwestern Medicine scientists have discovered that two key cellular structures, called mitochondria and lysosomes, come into direct contact with each other in the cell to regulate their respective functions.
The ALS / FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy - lysosome pathway.
The research described in this essay focused on understanding this pathway by identifying protein factors that form a lysosome - based signaling platform that positively and negatively regulates the function of the Rags.
Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.
Currently, Wang said her work is focused on two such metabolite - directed communication systems that regulate metabolic health and longevity: lysosome - to - nucleus retrograde lipid signals and microbe - to - host metabolite messages.