Sentences with phrase «regulation in cancer cells»

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Without this regulation, lack of Sxl expression in stem cells can result in the development of ovarian cancer.

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.

One class of immunotherapeutic drugs is known as «checkpoint» inhibitors, as they target checkpoints in immune system regulation to allow the body's natural defenses, such as white blood cells, to more effectively target the cancer.

She was on her way out to a pub after a scientific conference when she spotted Paul Nurse, who was working on cell - cycle regulation at Imperial Cancer Research Fund in London.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Andcancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD AndCancer Biology, senior author of the Nature paper and president of MD Anderson.

We will then seek to develop the most promising of these into novel drugs for cancers, such as those of the breast, where up - regulation of this c - FLIP is believed to be important in cancer cell proliferation.»

Although NRF2 has many benefits, loss of NRF2 regulation leads to high levels in certain cancer cells, such as some lung cancers, and it may help them migrate, Zhang says.

Such precise regulation of the cell cycle is lost in cancer cells.

Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

Tadashi Matsuda of Hokkaido University and his colleagues in Japan investigated human prostate cancer cells to determine if there is an unknown up - regulation mechanism in the EGFR pathway.

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

«The researchers now plan to team up with other world - leading experts in cancer signalling based in Manchester including Professor Nic Jones, Director of MCRC and Cancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental scancer signalling based in Manchester including Professor Nic Jones, Director of MCRC and Cancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental sCancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental stress.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in theCancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in thecancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

«Mutations in gene essential for cell regulation cause kidney cancer in children.»

In normal cells, the mTOR pathway can be turned on and off, but in some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulatioIn normal cells, the mTOR pathway can be turned on and off, but in some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulatioin some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulation.

Revealing functional networks of alternative splicing regulation in cancer (Valcárcel's group, Mol Cell 2013; Mol Cell 2015a: Mol Cell 2015b).

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF - a and the NF -?

In addition to Doñana Biological Station (EBD - CSIC), also taking part in the project were the National Center for Genomic Analysis (CNAG - CRG); the Centre for Genomic Regulation (CRG); the Spanish National Cancer Research Center (CNIO); the Evolutionary Genomics Group of the Hospital del Mar Medical Research Institute (IMIM); the Institute of Evolutionary Biology (IBE, CSIC - UPF); the University Institute of Oncology of Asturias (IUOPA); the Institut de Biotecnologia i de Biomedicina and the Unit of Cell Culture of the Autonomous University of Barcelona (UAB); the Biological Research Center (CIB - CSIC) and the Catalan Institution for Research and Advanced Studies (ICREAIn addition to Doñana Biological Station (EBD - CSIC), also taking part in the project were the National Center for Genomic Analysis (CNAG - CRG); the Centre for Genomic Regulation (CRG); the Spanish National Cancer Research Center (CNIO); the Evolutionary Genomics Group of the Hospital del Mar Medical Research Institute (IMIM); the Institute of Evolutionary Biology (IBE, CSIC - UPF); the University Institute of Oncology of Asturias (IUOPA); the Institut de Biotecnologia i de Biomedicina and the Unit of Cell Culture of the Autonomous University of Barcelona (UAB); the Biological Research Center (CIB - CSIC) and the Catalan Institution for Research and Advanced Studies (ICREAin the project were the National Center for Genomic Analysis (CNAG - CRG); the Centre for Genomic Regulation (CRG); the Spanish National Cancer Research Center (CNIO); the Evolutionary Genomics Group of the Hospital del Mar Medical Research Institute (IMIM); the Institute of Evolutionary Biology (IBE, CSIC - UPF); the University Institute of Oncology of Asturias (IUOPA); the Institut de Biotecnologia i de Biomedicina and the Unit of Cell Culture of the Autonomous University of Barcelona (UAB); the Biological Research Center (CIB - CSIC) and the Catalan Institution for Research and Advanced Studies (ICREA).

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

In 2016, the group of Prof. Zeißig proved the decisive role of gut bacteria in the regulation of intestinal stem cells and the development of colon canceIn 2016, the group of Prof. Zeißig proved the decisive role of gut bacteria in the regulation of intestinal stem cells and the development of colon cancein the regulation of intestinal stem cells and the development of colon cancer.

In the present work, our observations led us to conclude that inhibition of TRF2 abrogates the formation and maintenance of the spheroidal phenotype and loss of TRF2 results in down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell linIn the present work, our observations led us to conclude that inhibition of TRF2 abrogates the formation and maintenance of the spheroidal phenotype and loss of TRF2 results in down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell linin down regulation of CSC characteristics when exposed to DNA damaging environment in HCT116 colon cancer cell linin HCT116 colon cancer cell line.

Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.

In addition, breast cancer cells respond differently to S1P in terms of the regulation of actin cytoskeletal structureIn addition, breast cancer cells respond differently to S1P in terms of the regulation of actin cytoskeletal structurein terms of the regulation of actin cytoskeletal structures.

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

Our insight will substantially enhance our understanding of dynamic cell shape regulation for instance in the context of cell migration as in cancer metastasis or during morphogenesis.

It has a critical role in regulating cell proliferation, so understanding ERK regulation is central to efforts to design new cancer drugs and other disease therapies.

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).

Malfunctioning regulation of NF - KB has been linked to various types of cancer, including lung cancer, but due to its many functions in the cell, drugs that directly target NF - KB would likely cause severe side effects.

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

Zhu Q, Jin L, Casero RA, Davidson NE, Huang Y. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.

Three Scientific Programs provide focus in Gene Regulation & Cell Proliferation, Signal Transduction, and Cancer Genetics.

ABL kinases regulate cancer cell invasion (21), but it is unclear whether they play a role in the regulation of subsequent steps of the metastatic cascade.

Regardless, our data support a role for ABL kinases in the regulation of TAZ protein abundance and activity in breast cancer cells.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

Matsuzaki J, Gnjatic S, Mhawech - Fauceglia P, Beck A, Miller A, Tsuji T, Eppolito C, Qian F, Lele S, Shrikant P, Old LJ, Odunsi K. (2010) NY - ESO - 1 specific tumor infiltrating CD8 + T cells in human ovarian cancer: negative regulation by LAG - 3 and PD - 1.

The mutation damages the regulation of DNA in cells involved in the cancer — a form of epigenetic change.

Our final goal is to find ways to restore the correct gene regulation programs in immune cells, to enhance their function and eradicate cancer cells.

Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells.

The regulation of cell size and cell numbers is an important part of determining the size of organs in development, as well as of controlling cell over-proliferation in diseases such as cancer and diabetes.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

Zou's group was the first to show PD - L1 expression, regulation and functional blockade in dendritic cells in the human cancer microenvironment.

45) * Coe BP, * Lockwood WW, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer.

Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson's, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

Because Wnt signaling is involved in the regulation of proliferation and apoptosis, and miR - 150 is reported to regulate proliferation of breast cancer cells, we think that the functions of these microRNAs include the regulation of cell proliferation and apoptosis.

Regulation of aromatase and 5alpha - reductase by 25 - hydroxyvitamin D (3), 1alpha,25 - dihydroxyvitamin D (3), dexamethasone and progesterone in prostate cancer cells..