Lue, whose essay described
the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.
15/3: 30 Tissue - specific transcriptome - wide networks reflect joint
regulation of alternative splicing and gene expression.
Studies in Biology at University of Bern, Switzerland; PhD on
regulation of alternative splicing at the Karolinska Intitute, Stockholm, Sweden and at Uppsala University, Sweden; Postdoc on post-transcriptional mRNA surveillance at Brandeis University, Boston, USA; research group leader (since 2000) and full professor (since 2010) at the University of Bern, working on mRNA surveillance, turnover and splicing.
These mutated RNAs accumulate and alter
regulation of alternative splicing of numerous genes.
Not exact matches
To peel away at the intricate layers that govern the development
of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level
of molecular
regulation called
alternative splicing.
Revealing functional networks
of alternative splicing regulation in cancer (Valcárcel's group, Mol Cell 2013; Mol Cell 2015a: Mol Cell 2015b).
Since November 2013, as part
of SGC, Clara mainly investigates different subfamilies
of kinases involved in
alternative splicing through phosphorylation - mediated
regulation of SR proteins activity.
These include molecular evolution
of transcription factors or changes in transcriptional
regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution
of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity
of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns
of alternative splicing of specific genes (Calarco et al., 2007).