Sentences with phrase «regulation of gene expression as»

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«The reversible nature of the m6A methylmark adds a new layer to the regulation of gene expression now termed «epitranscriptomics» and warrants further research to establish links with human disease such as cancer,» adds Dr Irmgard Haussmann of Coventry University.

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

A vital and ancient component of gene regulation, miRNA tunes the expression of as many as 30 - 60 % of mammalian protein - encoding genes, usually silencing them.

Scientists have discovered many points of regulation in the process of using a specific DNA template to make a protein, known as gene expression, that allow the cell to control how much of a certain protein is made at a certain time.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

This could be an indication of a controlled expression of genes responsible for calcification during daytime, as evidenced by the up - regulation of genes associated with the cartilage and bone biogenesis process.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNAExpression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNAexpression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

As RNA - binding proteins are still systematically understudied, we will provide important insights of the roles of a key player in post-transcriptional regulation of gene expression.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

However, since most of the disease variants fall outside the gene coding sequences, thereby implicating gene expression regulation as the causal mechanism, the functional interpretation of the exact role of the associated variants remains to be determined.

Whole genome expression data of livers of wildtype and PPARα − / − mice fasted for 24 h served as positive control for PPARα - dependent gene regulation.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

In addition to its activities as an antioxidant, vitamin E is involved in immune function, cell signaling, regulation of gene expression, and possibly other metabolic processes.

High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the understanding of synergistic effects of SCFA and phytosterols in glucose regulation and cholesterol homeostasisis important to our understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and gene expression

High fibre diets also contain various fatty acids such as the short chain fatty acids (SCFA) and the understanding of synergistic effects of SCFA and phytosterols in glucose regulation and cholesterol homeostasisis important to our understanding of diet, lifestyle and drugs in relation to peripheral amyloidosis and gene expression that play an early role in the development of AD.

-LSB-...] Our data provide evidence that the distal part of the gut has the ability to sense nutrients such as butyrate, resulting in the up - regulation of PYY and proglucagon gene expression.»

We examine alterations in biological stress regulatory systems; alterations in the neural regulation of stress responses; and expression of genes related to stress responses, both as latent indicators of impending health risks and as indicators of psychological and biological stress - reactive processes that may accelerate those risks.