Sentences with phrase «regulation of gene expression through»

Not exact matches

The regulation of gene expression, for example, is extremely difficult to study through the genome alone.

At the nucleic acid level, understanding the precise regulation of genes through analysis of gene expression data will be of utmost importance.

DDX3 enhances p21waf1 / cip1 gene expression through up - regulation of promoter activity of p21waf1 / cip1.

Expression changes of these genes suggest a possible form of gene regulation through the alteration of the chromatin structure.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

cell types may have evolved through cooption of temporal gene regulation in an ancestor whose different phases were converted into germ - and soma - specific expression programs.

«In a way, we're modeling one mechanism through which genes affect disease or traits, which is the regulation of gene expression level.»

These results suggest that V. carteri cell types may have evolved through cooption of temporal gene regulation in an ancestor whose different phases were converted into germ - and soma - specific expression programs.

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Although the mechanism of age - related decline in DNA repair capacity is unknown, growing evidence suggests that epigenetic events (e.g., DNA methylation) contribute to the ageing process and may be functionally important through the regulation of the expression of DNA repair genes.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment diThrough this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dithrough direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.