Sentences with phrase «regulation of genes involved»

Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.

To determine whether shifts in the balance of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and regulation of genes involved in anterior - posterior patterning in pectoral fins of catsharks, with those of mice.

For example, the study found down - regulation of genes involved in interferon tau, the major signal of pregnancy recognition.

Not exact matches

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.

Epigenetic mechanisms give tortoiseshell cats their markings, but are also involved in our development in the womb and the day - to - day regulation of our genes

One aspect of gene regulation involves enzymes placing chemical tags or modifications on histone proteins — which control a cell's access to the DNA sequences that make up a gene.

«Rapamycin affected the expression of genes involved in calcium regulation, mitochondrial metabolism, hypertrophy and inflammation,» said Melov.

It involves detecting micro-RNAs (miRNAs): small, non-coding RNA molecules that are important in the regulation of gene expression.

«Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he genes,» he says.

Now researchers have identified a mutation in the human ATP4a gene that is involved in the gastric acid secretion regulation and has been identified as responsible of an aggressive form of inherited, early - onset gastric NET.

Within the last decade, many scientists have come to believe that DNA methylation — a mode of genetic regulation in which chemical tags turn genes on or off — is involved.

In 1993, RIMB had 27 members, 25 of whom were involved with gene regulation and development.

The second insight involved changes in the evolution of gene regulation: As social complexity increased, so did the speed of changes to parts of the genome involved in regulating gene activity, located in the promoters of the genes, the researchers report.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

Now researchers can look to see whether those variants are involved in regulation of some sort and if so, what genes are being regulated.

After five years of research, they identified the gene regulation pathway, which involves the body's sodium sensor called Nax (scn7a) that triggers inflammation.

A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

Also, because it is involved in such a critical step in the synthesis pathway, the regulation of the DSYB gene by environmental conditions is of great significance in determining how much DMSP is ultimately produced.»

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

One of the most cited examples is the mutation involved in lactose tolerance, which is also caused by regulation from outside the gene.

At present, the regulation of gene drive research does not fit within the purview of any of the U.S. agencies involved in the Coordinated Framework for the Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protectiregulation of gene drive research does not fit within the purview of any of the U.S. agencies involved in the Coordinated Framework for the Regulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental ProtectiRegulation of Biotechnology, which includes the Food and Drug Administration, U.S. Department of Agriculture, and the U.S. Environmental Protection Agency.

In a non-disease state, TDP - 43 is an important protein involved in various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of genes.

Interestingly, this process involves the structures of the Pax3 protein that bind to DNA, but this process does not involve DNA binding or regulation of gene expression.»

Epigenetics involves the regulation of genomic functions, including gene expression.

His research interests involve pharmacogenomics for hemoglobinopathies and neuropsychiatric disorders, transcriptional regulation of human fetal globin genes and genotype - phenotype correlation in human genetic disorders.

References 24 and 25 describe the positive - feedback regulation of type I IFN gene induction, which involves the expression and activation of IRF7.

Genes that regulate Smn protein in mice may be involved in the regulation of SMN2 protein in humans.

Regulation of transcript levels of the Arabidopsis cytochrome p450 genes involved in brassinosteroid biosynthesis

Since they confer regulation on the majority of human genes, it is not surprising that microRNAs are involved in numerous biological processes, including cardiovascular, immunological, neurodegenerative, and psychiatric diseases and cancer.

Using drug repurposing, Yoshimura's group not only identified circadian rhythm changing drugs, but also succeeded in identifying genes that are involved in the regulation of the circadian clock.

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

Finally, we will conduct an RNAi based screen to identify novel factors that are involved in the regulation of sestrin gene expression and that may act in conjunction with p53.

Once again, the genes that are subject to HAR2 regulation are still unclear, although GBX2, a transcription factor that controls proper expression of genes involved in embryo morphogenesis, is one promising candidate.

A homeobox is a DNA sequence found within genes that are involved in the regulation of development (morphogenesis) of animals, fungi and plants.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Leemor Joshua — Tor of the Howard Hughes Medical Institute and Cold Spring Harbor Laboratory wins award for her work in resolving the structures of proteins involved in gene silencing, DNA replication and gene regulation in yeast.

The genes MDR1 and NANOG, both involved in the regulation and expression of efflux pump mechanisms, were significantly suppressed.

Whereas IRF - 9 functions as an adaptor for tethering the different STAT dimers to ISRE, other members of IRF family have also been shown to be involved in the regulation of ISRE - containing genes.

The Marsh - Armstrong laboratory studies molecular mechanisms involved in gene regulation, development and disease of the central nervous system, focusing principally on the retina.

Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription

We have identified common alleles of genes that contribute significantly to both of the principal processes involved in obesity — basic energy metabolism on the one hand and the regulation of appetite on the other,» said Kari Stefansson, CEO of deCODE.

Using an RNA interference screen, Swanton and his colleagues identified a set of genes involved in the regulation of mitotic arrest and in the metabolism of ceramides, lipid molecules abundant in cell membranes that influence whether tumors are sensitive to certain chemotherapy agents.

The links between the many genes involved in the maintenance of pluripotency and the regulation of ES cell differentiation programs are not well characterized.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].

There was no significant enrichment of genes in any functional category; however, GO annotations revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of cell differentiation,» «Wnt receptor signaling pathway,» and «gland development.»

In addition to its activities as an antioxidant, vitamin E is involved in immune function, cell signaling, regulation of gene expression, and possibly other metabolic processes.