Recent findings suggest that tumor associated stroma is another important
regulator of tumor growth and progression which may also modulate the recruitment, activation status and retention of immune cells in the tumor microenvironment.
LKB1, originally identified as a
tumor suppressor protein, is currently thought as a critical
regulator of cellular metabolism and
growth by controlling the activity
of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.