Sentences with phrase «regulator transcription factors»

The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.

The regulators included proteins known as master regulator transcription factors.

The approach helped to discover and nominate Lmx1A as a master regulator transcription factor of Group 4 tumors, which led to the identification of the likely Group 4 tumor cells of origin.

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

The key regulator they identified were the RFX transcription factors.

SIK3 controls G6PD in synergy with another important regulator of sugar tolerance, the sugar - sensing transcription factor complex Mondo - Mlx.

Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors.

Upon discovery of the transcription factor SUSIBA2, for SUgar SIgnaling in BArley 2, further investigation revealed it was a type known as a master regulator.

The sequences of these enhancers were enriched for many of the same transcription factor (TF) binding motifs; the authors could propose upstream regulators for about half of the enhancer modules they observed.

The transcriptional regulator megakaryoblastic leukemia - 1 mediates serum response factor - independent activation of tenascin - C transcription by mechanical stress.

Frank Mercurio and Anjana Rao report the cloning of the IκB kinases IKK - 1 and IKK - 2, the essential upstream regulators of the transcription factor NFκB.

Over the past decade, we have also demonstrated that the zinc finger transcription factor KLF15 functions as a nodal regulator of cardiovascular plasticity and multi-organ metabolic homeostasis.

Defined the transcription factor KLF15 as a nodal regulator of cardiovascular function and multi-organ metabolic homeostasis

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

This is the master regulator of insect development, and it was the first transcription factor ever discovered.

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

For example, a research team last year used LINCS data to identify the role of a critical transcription regulator, heat shock factor 1 (HSF1), in cancer.

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

Surprisingly, we found that the determinant for this wing size difference is located in the non-coding region between two known transcription factors, the master sex determining gene doublesex and neurogenesis regulator prospero.

We then found that the transcription factors Smad1, Smad5 and Zeb2 were also experimentally validated targets of miR - 181a [30,31,34], which are key downstream regulators of BMP / GDF signalling [32,33,35,36].

They showed genetically that there was an additional response coming from the transcription factor — Forkhead box O (Foxo)-- which in turn enhances the transcription of one of the translational regulators: eukaryotic initiation factor 4E binding protein (4E - BP).

Structure of an MmyB - like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.