Sentences with phrase «regulators of cell identity»
These master regulators of cell identity include important developmental proteins, such as FOX and SOX families.
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The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.
After 15 days, a subset of cells expressed regulators of RGC differentiation (Atoh7, Brn3b, and Islet1), while a smaller subset co-expressed Brn3b and the mature RGC marker Thy1, thus confirming a RGC identity.
This research, which was performed at the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, has also revealed the precise role of Sox2 as a master regulator that controls the identity of neural stem cells.