Sentences with phrase «regulatory circuitries»

The three stages of CD8 + T cell development are well known, but the current study identifies a detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving genes to transcribe proteins to carry out biological processes.

Furthermore, C326S ferroportin mutant mice with a disrupted hepcidin / ferroportin regulatory circuitry respond to injection of the TLR2 / 6 ligands FSL1 or PAM3CSK4 by ferroportin down regulation and a reduction of serum iron levels.

Understanding of leukemias also could be aided by insight into this regulatory circuitry, Singh said.

Understanding of leukemias also could be aided by insight into the hematopoietic stem cell regulatory circuitry, said Singh.

An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.

Overt aggression, violence and cruelty reflect abnormalities in the emotion regulatory circuitry of the brain as a result of an abusive childhood.