Not exact matches
They also demonstrated significant advantages of editing gene
regulatory sequences in their native location to uncover new functionalities that could lead to a better understanding of how
control switches work to turn genes on and off in the body.
The findings are especially important as they highlight the discovery of a
regulatory sequence, termed the J element, that
controls class I gene expression of many more genes than the counterparts that regulate class II gene expression.
The National Human Genome Research Institute, part of the National Institutes of Health, has awarded $ 9.1 million over four years to a research team led by the University of Chicago to identify all
regulatory elements, the DNA
sequences that
control when and where specific genes get turned on or off, in the fruit fly genome.
A unique
sequence in the N - terminal
regulatory region
controls the nuclear localization of KLF8 by cooperating with the C - terminal zinc - fingers.
The complete genome
sequence has revealed an unusual breadth (in number and in effect) of DNA inversion events that potentially
control expression of many different components, including surface and secreted components,
regulatory molecules, and restriction - modification proteins.
Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte
regulatory genomic landscape with
regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA
sequences utilized in the
control of melanocyte gene expression.
I support this
sequence, knowing that if the
sequence is reversed,
control of the
regulatory process would be lost to government.