Sentences with phrase «regulatory sequence variations»
Identification of cis - regulatory sequence variations in individual genome sequences.
http://bcchr.ca/ Not exact matches
More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...
However, several genetic mechanisms — including the evolution of protein - coding sequences and gene duplication, as well as the evolution of regulatory sequences — are sources of variation in all species and contribute to organismal adaptation.
Montgomery, S.B., Lappalainen, T., Gutierrez - Arcelus, M. & Dermitzakis, E.T. Rare and common regulatory variation in population - scale sequenced human genomes.
Large - scale genome sequencing coupled with RNA - seq, however, would provide the opportunity to comprehensively identify and characterize regulatory variation.
The resulting datasets of regulatory genomic sequence will provide a valuable resource in determining how non-coding DNA sequence variation may impact an individual's capacity to drive appropriate gene expression.
In relation to the association of infant attachment with a promoter polymorphism of the serotonin transporter gene, we have mentioned that gene expression may be affected by variation in the DNA sequence of the regulatory region of the gene.