Furthermore, an examination of the histone code revealed that the
regulatory genomic region of the transcription factors (ETS / GATA / SOX) was
found to have gradually
switched from a «brake histone mark,» which suppresses transcription, to an «accelerator histone mark,» which activates transcription, while in the process of differentiating into the vascular endothelium.
«We expect to
find that many genetic changes causing a disorder are within
regulatory regions, or
switches, that affect how much protein is produced or when the protein is produced, rather than affecting the structure of the protein itself.