Sentences with phrase «reject transplanted cells»

People are also less likely to reject transplanted cells from their own bodies.

For many scientists, the clinical promise of stem cells has been dampened by very real concerns that the immune system will reject the transplanted cells before they could render any long - term benefit.

Not exact matches

As the immune cells in the recipient recognize transplanted cells as foreign, they mount an inflammatory response that can lead to the body rejecting the transplant.

Although such harvested cells could be cultured as say, liver cells for treating hepatitis or dopamine - producing cells for Parkinson's, the resulting transplants would likely be rejected by patients» immune systems.

One promising approach focused on a drug called TOL - 101, which inhibits the immune cells responsible for rejecting transplanted tissue.

Eye diseases — such as age - related macular degeneration, as well as a genetic condition called Stargardt's macular dystrophy that afflicts young people — are considered excellent candidates for stem cell therapy because the eye is an immune - privileged site, meaning transplanted cells are not as likely to be rejected as foreign compared with transplants elsewhere.

For one thing, researchers learned that fetal T cells are, in fact, able to reject foreign invaders — whether a microbe or a cell transplant — more readily than thought.

This suggested that Tregs act as a «brake» that prevents other immune cells from targeting and rejecting the second transplant.

«Stem cell therapy may help recondition lungs previously rejected for transplant.»

Transplanted embryonic stem cells are ethically cleaner, but they have a genetic makeup different from the patient's own, so they could be violently rejected by the immune system.

One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.

For one, transplanted donor cells can be rejected just like a donor heart, putting the patient at risk of disease and often requiring powerful immune suppressants, with all the attendant side effects and risks.

One is the risk that the transplant recipient might reject the cells, or that the implanted cells might also affect other functions.

T cells normally attack tissue they do not recognise as «self,» causing organs which have been transplanted from other donors to be rejected.

From an entire organ to a dose of embryonic stem cells, if the tissue's DNA came from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive drugs.

Because these cells are derived from a patient's own cells, scientists had assumed that they wouldn't be rejected — a common problem with organ transplants.

Indeed, our results indicate that adoptive transfer of CD8 + T cells from CD4 KO mice that had rejected corneal allografts resulted in the rejection of 95 % of the corneal allografts transplanted to athymic recipients.

BALB / c corneal allografts were transplanted to C57BL / 6 beige nude mice that received either CD8 − or CD8 + T cells from C57BL / 6 CD4 knockout (KO) mice that had rejected BALB / c corneal allografts.

Often used to prevent patients» bodies from rejecting transplanted organs, rapamycin works by increasing the numbers of regulatory T cells and block other aggressive types of T cells.

This ensures your body's defences do not attack and reject the donor cells after they are transplanted.

Cells can be removed from a patient and used to create new organs for transplant that will not be rejected by the patient's body.

The team used a specific mouse strain that is healthy but it is lacking in a specific immune cell receptor, which makes the mouse unable to reject transplanted foreign cells.

Researchers from the Buck Institute report one of the first demonstrations of long - term vision restoration in blind mice by transplanting photoreceptors derived from human stem cells and blocking the immune response that causes transplanted cells to be rejected by the recipient.

The Joslin researchers then transplanted these modified human diabetic cells into wounds in mice models of diabetes that also had suppressed immune systems so that they didn't reject human cells.

At least in theory, producing regulatory T cells could promote immune tolerance and prevent the body from rejecting newly transplanted cells.