Sentences with phrase «related adverse effect»

About 20 percent experienced a serious treatment - related adverse effect but none was life - threatening.

«Shortening treatment regimens and reducing the required doses may be a promising strategy to reduce the incidence of bedaquiline - related adverse effects and thereby improve multidrug - resistant TB treatment outcomes,» says Gupta.

Okyanos therapies have been shown to be safe and efficacious in scientific and / or medical literature for the conditions we treat, and there have been zero reports of cell - related adverse effects using a patient's own adipose - derived stem and regenerative cells (ADRCs).

The benefits of vaccination are usually considered to far outweigh the relatively small risk of vaccine - related adverse effects.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Alcoa had voluntarily shut - off the plant's burner in 2002 after a number of multi-million dollar compensation claims were made against the company by workers relating to adverse health effects.

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.

As a result, political instability, labor strikes, natural disasters or other events resulting in the disruption of trade or transportation from other countries or the imposition of additional regulations relating to duties upon imports could cause significant delays or interruptions in the supply of our merchandise or increase our costs, either of which could have an adverse effect on our business.

In addition, any change in these estimates or their related assumptions could have an adverse effect on our operating results.

The Enterprise Compensation Committee discharges the board of directors» responsibilities relating to the compensation of our executives and directors; reviews and discusses with management the Compensation Discussion and Analysis and performs other reviews and analyses and makes additional disclosures as required of compensation committees by the rules of the SEC or applicable exchange listing requirements; provides general oversight of our compensation structure, including our equity compensation plans and benefits programs, and confirms that these plans and programs do not encourage risk taking that is reasonably likely to have a material adverse effect on Hewlett Packard Enterprise; reviews and provides guidance on our human resources programs; and retains and approves the retention terms of the Enterprise Compensation Committee's independent compensation consultants and other independent compensation experts.

Fetal alcohol spectrum disorders (FASDs) is an umbrella term that encompasses several diagnostic categories related to the adverse effects resulting from in utero exposure to alcohol.

The enduring effects of abuse and related adverse experiences in childhood: a convergence of evidence from neurobiology and epidemiology

No adverse effects, such as anemia, excessive bone loss, or menstrual disorders were noted; in fact, both trials led to improvements in mood and health - related quality of life.

The increase in free time and the changes in the social networks related to retirement can have either adverse or positive effects on public health, says Academy Research Fellow, Docent Sari Stenholm from the University of Turku.

The researchers did not observe any adverse effects on pregnancy or birth related to 25HC treatment.

«What is intriguing about this research is that childhood trauma had an effect on impulse control that was in both groups, meaning that it is independent of bipolar illness and more strongly related to adverse childhood experiences,» Marshall says.

«Couples planning a pregnancy might consider limiting their consumption of these beverages, especially because they are also related to other adverse health effects.»

The authors note that clinicians must consider medication efficacy, potential side effects, and possible medication - related adverse events when prescribing acute medications for migraine.

Professor Marco Metra, director of the Institute of Cardiology at the University and Civil Hospital of Brescia, Italy and co-principal investigator of RELAX - AHF, said: «We have reported that all of these adverse effects of a worsening heart failure event are related to increased overall mortality and that a worsening heart failure event itself is related to a two-fold increased risk of dying in 180 days.»

No children discontinued the study due to side effects or had a severe or life - threatening adverse event related to the study drug.

No scientific evidence relating to the benefits and possible adverse effects of long - term use in higher doses yet exists.

Finally, third, changes in host pathology that can relate either to adverse effects generated by the invading microbe or indeed the host immune response itself [5].

Given the potential for adverse mental affects of living liver donors» ambivalence, the present study investigated the effect of social support and concerns related to the donation process.

Even so, future disclosures will include information detailing the risk the company faces from «potential laws and regulations relating to climate change or coal, which could result in materially adverse effects on its markets or [the] company,» it said.

Adverse effects of coal combustion related fine particulate matter (PM 2.5) on nematode Caenorhabditis elegans.

«The side effects were quite high with the combination, with about 30 % of patients discontinuing due to treatment - related adverse events, as compared to 5 % with nivolumab and 13 % for ipilimumab.»

These immune - related adverse events can be quite serious and even fatal, but are typically reversible when effective treatment guidelines on side effect management are followed.

Scholar Rock has demonstrated that SRK - 015 selectively binds to the latent forms of myostatin, inhibiting activation while avoiding interaction with other closely related members of the TGFβ superfamily that may lead to unintended adverse effects.

The researchers suspect that the sudden change in blood calcium levels after taking a supplement brings about the adverse effect, instead of it being related to the total amount of calcium taken.

On the other hand, healthy aging and longevity may be related to reduced levels of inflammation and / or strong protective mechanisms that guard against its adverse effects.

«It is possible that older adults may not be able to distinguish between muscle pain related to a statin effect or an effect of aging and therefore adverse effects of statins in older adults may be under - reported.»

In general, the number and severity of adverse effects are related to the overall exposure, measured by length of therapy and blood drug concentration.

Their food related problems might reflect an adverse additive effect of multiple modest hypersensitivity reactions mediated, for instance, by immune complexes promoting autoimmune reactions in the joints.»

Adverse effects were largely GI - related, including bloating and diarrhea (19).

Background: Interventions to attenuate the adverse effects of age - related loss of skeletal muscle and function include increased physical activity and nutritional supplementation.

After reviewing the clinical and experimental evidence relating to the possible mechanisms of action of acupuncture on polycystic ovarian syndrome, it is clear that acupuncture modulates the nervous system, the endocrine system and the neuroendocrine system; and that acupuncture has been demonstrated to be a suitable alternative or complement to pharmacological induction of ovulation, without adverse side effects.»

As a «victim» of T2D I have been ketogenic for more than 4 years with no adverse health effects as demonstrated by extensive laboratory testing, CT scans and MRI scans (both for other reasons not related to ketogenic nutrition or T2D).

I'm interested to know what this could be related to since it seems quite a few parents here and elsewhere have reported adverse effects when feeding their babies egg yolks.

Watford UTC's three - student team of 17 - 19 year olds identified the teaching profession as a stressful occupation for which the https://www.nasuwt.org.uk/article-listing/action-needed-to-reduce-stress-faced-by-teachers.html BioBand could assist, with research finding < https://www.nasuwt.org.uk/article-listing/action-needed-to-reduce-stress-faced-by-teachers.html > 83 % of teachers have experienced work related stress, 67 % say the job has had an adverse effect on their mental and physical health and 5 % have been hospitalised as a result of the conditions.

We are unable to tell why there are such strong gender differences in the effects we estimate, though we suspect it is related to emerging evidence that boys are more sensitive to adverse shocks that occur when they are young than are girls.

The enduring effects of abuse and related adverse experiences in childhood.

A child may be found eligible for special education and related services as a child with an intellectual disability if there is an adverse effect on the child's educational performance due to documented characteristics of intellectual disabilities which are described as a significantly sub average general intellectual functioning, existing concurrently with deficits in adaptive behavior and manifested during the developmental period.

A Child with a Disability or Student with a Disability means a child, birth to age 21, evaluated in accordance with IDEA or COMAR having any of the following disabilities, causing an adverse effect on the child's educational performance resulting in the need of special education and related services:

A child may be found eligible for special education and related services as a child with multiple disabilities if there is an adverse effect on the child's educational performance due to documented characteristics of multiple disabilities which are described as simultaneous impairments (Such as intellectual disability with blindness, intellectual disability with orthopedic impairment), the combination of which causes such severe educational needs that they can not be accommodated in special education programs solely for one of the impairments (this terms does not include deaf - blindness).

How might you use the information related to the adverse effects of poverty on lives and learning in your classroom and school?

Investments in illiquid securities pose risks related to uncertainty in valuations, volatile market prices, and limitations on resale that may have an adverse effect on the ability of the fund to dispose of the securities promptly or at reasonable prices.

If the landlord is ultimately successful in its complaint, we may be liable for significant damages in connection with the alleged early termination of the lease and may lose assets related to the biopharmaceutical manufacturing facility we have constructed within the leased premises, which could have a material adverse effect on the our financial position, results of operations or cash flows.

NSAIDs block both the «bad prostaglandins» and the «good prostaglandins», therefore, these drugs can cause adverse effects related to the lack of «good prostaglandins», such as gastric ulcers.