Sentences with phrase «related brain proteins»

You know that missing out on a good night's sleep can lead to brain fog the next day, but research also suggests that disturbed sleep over time may be linked to a buildup of Alzheimer's - related brain proteins.

Not exact matches

Plus, new research suggests that disrupting sleep during certain parts of the night can quickly raise levels of Alzheimer's - related proteins in the brain and spinal fluid.

Bierut: The brain is a very complex organ and what's clear is these different types of brain wave patterns are related to numerous complex in our actions between neurotransmitters and some of the brain receptors, and it's some of the balance between how much of these proteins are produced — how are they regulated — are likely to be involved in some of these biologic predispositions.

Flickering light kicks off brain waves that clean a protein related to Alzheimer's disease out of mice's brains, a new study shows.

This week in Science we profile Yale School of Medicine neuropathologist Laura Manuelidis, who has spent her career fighting the consensus that misfolded proteins called prions cause «mad cow disease» and other related brain diseases.

This turned out to be a normal protein in the cells of organisms throughout the animal kingdom — but in brains infected with scrapie and related diseases it turns up in both a normal, soluble form and an abnormal, insoluble form which accumulates in deposits that eventually kill the cells.

In 2010 biologist Valerie Hu of the George Washington University Medical Center and her colleagues found that brains of people with autism have low levels of a protein produced by a gene called retinoic acid — related orphan receptor - alpha (RORA).

There is also genetic evidence relating to a protein called neuregulin 1, which is involved in brain development in the womb.

Researchers at the University of Pittsburgh School of Medicine have uncovered a major reason why the Parkinson's - related protein alpha - synuclein, a major constituent of the Lewy bodies that are the pathological hallmark of Parkinson's disease (PD), is toxic to neurons in the brain.

The group» finding that the impaired intracellular protein trafficking leads to neuropsychiatric disorders - related abnormal higher brain functions has high impact on the fields of psychiatry, basic medical sciences, and pharmaceutical sciences.

The research group showed that a molecule, ARHGAP33 regulates synaptic functions and behaviors via intracellular protein trafficking and that the lack of ARHGAP33 causes neuropsychiatric disorder - related impaired higher brain functions.

If something similar happens in humans, scientists say, methods for countering the protein may hold promise for treating age - related brain decline.

A protein in blood can repair age - related damage in the brains and muscles of old mice, returning them to a more youthful state.

• Kappa opioid receptor, a protein on the surface of brain cells that is centrally involved in pleasure as well as in pain, addiction, depression, psychosis and related conditions.

Based on studies of other genes related to FOXP2, the authors suggest that the loss of functioning protein from one copy of this gene might disrupt the proper growth of key speech and language structures in the brain.

The fibrils of the body's own amyloid beta (Aβ) protein are the main constituent of Alzheimer's disease related and characteristic pathological protein deposits in the brain.

The researchers scanned the entire brain and discovered that memories of alcohol consumption — often prompted by external stimuli — caused activation of this protein in specific regions of the frontal cortex, the area of the brain related to memory processing, as well as in the nucleus of the amygdala, which is responsible for emotional memories and involved in the emotional symptoms related to withdrawal.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

Over-activation of the inflammatory protein nuclear factor κB (NF - κB) in the brain region leads to a number of aging - related changes in mice, from cognitive decline to muscle weakness.

Elevated levels of the brain protein tau following a sport - related concussion are associated with a...

What makes tau and NF - L, as well as some related proteins, such as S100 - B and GFAP (glial fibrillary acidic protein), stand out is that they are not commonly found in organs other than the brain and central nervous system.

Related studies have elucidated how proteins that build up to abnormally high levels in the brain of Alzheimer's patients — amyloid beta, tau and alpha - synuclein — interact to disrupt brain function and promote memory loss.

Previous research by Dr. Akassoglou revealed that MS is linked to elevated levels of blood clotting - related proteins in the brain.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Researchers led by St. Jude Children's Research Hospital scientists have worked out how a crucial cancer - related protein, a «histone writer» called Ezh2, plays a role in suppressing as well as driving the most aggressive form of the brain tumor medulloblastoma.

A positron emission tomography scan was also conducted to detect the presence of amyloid plaques and Alzheimer's - related proteins in the brain.

-- Protein contributes to brain health, improves blood sugar levels and even protects against age - related cognitive decline.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

Your molecular clock is ticking faster 22.11.2009 High vitamin D level lengthens life expectancy of elderly Dutch 21.11.2009 Constant fight against appetite reduces life expectancy 09.11.2009 Stress reduces life expectancy at molecular level 07.11.2009 Animal study: melatonin extends lifespan 25.10.2009 Fish fatty acids reduce age - related physical performance decline 24.10.2009 Old muscles weaker, but tire less quickly than young ones 23.10.2009 How creatine lengthens your lifespan 20.10.2009 Melatonin keeps brain cells young 03.10.2009 Long marriage adds years to your life 18.09.2009 Drink three cups of tea a day and add five years to your life 11.09.2009 Life extending bacteria found in gut of Chinese centenarians 08.08.2009 Your initials determine how old you get 30.07.2009 Lecithin anti-aging supplement keeps hearing sharp 18.06.2009 Live ten years longer with just one multivitamin pill per day 06.06.2009 Life - extending effect of virgin olive oil shown in fat rats 22.05.2009 Daily dose of Echinacea lengthens life expectancy 24.04.2009 The less you sit, the older you'll get 21.04.2009 Animal study: nori contains life prolonging substance 06.04.2009 Vegetarianism is healthy, but not because of lack of animal protein 27.03.2009 Meditation lengthens lifespan 20.02.2009 Live longer with healthy fats 30.12.2008 Vitamin D delays aging at genetic level 28.12.2008 Physical exercise delays molecular aging by ten years 25.12.2008 How a low - carb diet helps against aging 23.12.2008 Vitamin D extends your life expectancy 22.12.2008 Too much growth hormone reduces life expectancy 07.11.2008 S - Words extend lifespan of writers and psychologists 11.10.2008 Creatine extends lifespan of mice 08.10.2008 Slim - waisted rats live longer 23.09.2008 Gingko lengthens rats» lifespan 12.09.2008 Strong men live longer 31.08.2008 Male orgasm prolongs life 23.08.2008 Ginkgo prolongs life 17.08.2008 Ginkgo protects the elderly against the first signs of Alzheimer's 16.08.2008

Cats require meat proteins in their diet, and those who don't receive sufficient meat protein have a higher risk of heart disease, brain damage and blindness, and many other health problems related to nutritional deficiency.