Not exact matches
Molecular
mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron -
related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and
cellular models and patients» biological samples.
Beyond
cellular senescence, we are uncovering additional underlying
mechanisms that contribute to age -
related diseases including:
Dr. Mucke has spent most of his career uncovering the molecular and
cellular mechanisms that cause memory loss and behavioral abnormalities in Alzheimer's disease and
related conditions.
Topics such as the
mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age -
related atrophy are examined using a large variety of
cellular, molecular and whole - animal in vivo assays of function.
To achieve this goal, the center's clinical and basic investigators are engaging in four distinct yet synergistic projects: 1) identifying
mechanisms of abnormal cell proliferation, 2) examining the role of thrombosis in the development of PAH, 3) studying the role of nitric oxide deficiency in PAH, and 4) testing two existing drugs to restore lost
cellular function due to a genetic mutation
related to PAH.
It is likely that these genes are components of
related molecular or
cellular pathways, or they might be targets of common regulatory
mechanisms, or both [52]--[54].
The Assisi Loop 2.0 uses patented targeted pulsed electromagnetic field (tPEMF) technology that has been demonstrated through laboratory testing to have a proven effect on the known biochemical and
cellular mechanisms of action
related to inflammation, with results published in peer - reviewed journals.