Sentences with phrase «related frailty»

Loss of immune function with age is an important component of age - related frailty, and even partially compensating for this decline might be very beneficial.

If the findings translate to humans, this restoration of muscle mass could help to combat some of the effects of age - related frailty, which often lead to osteoporosis and other debilitating conditions.

Not exact matches

Chronic low - grade inflammation is also associated with greater risk for several age - related diseases, including cardiovascular disorders, diabetes, certain cancers, autoimmune diseases, frailty, dementia and early mortality.

Our results demonstrate that these prior findings were less likely to be directly related to RA and were likely a phenomenon of frailty and aging of the general population.»

«What makes our findings significant is that these autoantibodies, which are a good predictor of frailty, are also a known mechanism for promoting chronic inflammation, which underlies a number of diseases and pathologies, especially aging - related conditions,» says Fedarko.

The accumulation of aging - associated frailty can occur independently of the acquisition of age - related diseases; however, the risk of the latter is increased in a frail organism and can accelerate aging.

So, what causes the chronic inflammation that leads to age - related disease and frailty?

Conclusion «In conclusion, among older adults, these data suggest that frailty may be more strongly related to inflammation and the inflammatory index than age», write the researchers.

The adult age - related clinical syndrome of growth hormone deficiency includes increased fat mass, decreased muscle mass and strength, decreased bone density, elevated lipids, insulin resistance, decreased psychosocial well - being and depression, fatigue, increased social isolation, inability to handle stress, cardiovascular disease, memory decline, overall deterioration in quality of life, frailty, thin dry skin, increased wrinkles, and diminished exercise tolerance.

Mortal quandaries are part and parcel for Woody Allen, but rarely has a character so convincingly examined his or her own frailty as it directly relates to old age, not necessarily along existential lines, but regarding the effects of natural mental and physical fatigue.

Also, there may be cultural issues related to the care recipient's frailty or illness, such as a different understanding of dementia, and accessing carer services outside the family or cultural group may not be culturally acceptable.

Although greater early local production of proinflammatory cytokines at wound sites is beneficial because it is associated with enhanced healing, greater systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31

These changes are important because both stressors and depression can sensitize the inflammatory response in such a way that they produce heightened responsiveness to stressful events as well as antigen challenge.25, 27,28,60 Furthermore, more frequent or persistent stress - related changes in plasma levels of these key cytokines have broad implications for health; elevated levels of proinflammatory cytokines have been linked to a variety of age - related disease, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, and frailty and functional decline.29 Moreover, inflammatory activation can enhance development of depressive symptoms.30, 31 Thus, relationships characterized by hostility, repeated conflicts, and heightened IL - 6 levels could have negative consequences for both physical and mental health.