Sentences with phrase «related gene affects»

Each obesity - related gene affects a different aspect of weight control.

Not exact matches

Habit then uses blood samples and DNA from a cheek swab to glean details on glucose levels and obesity - related genes, among other factors that could affect metabolism.

Why SIRT6 didn't affect females is a puzzle, but may be related to differences in genes that regulate ageing in males and females (Nature, DOI: 10.1038 / nature10815).

The researchers identified two genes related to blood vessel inflammation that confer risk of DSS, and four genes related to drug metabolism that affect risk of DF.

Genetic cues from male Aedes aegypti mosquitoes passed on during sex affect which genes are turned on or off in a females» reproductive tract post-mating, including genes related to blood feeding, egg development and immune defense, according to new Cornell research.

Together, we related how biophysical and biochemical properties affected by the SRY mutation relate to the regulation of a gene - regulatory network in a biological system.»

It now appears that the clocks and clock - related genes — some 20 such genes have been identified — affect virtually all of the cells» metabolic pathways, from blood sugar regulation to cholesterol production.

The search for autism - related genes has led to stunning evidence of the complexity of the disease, which is estimated to affect one in every 150 children born worldwide.

«If you can find a gene for blond hair that exists in Melanesia and nowhere else,» Myles says, «then there's no reason why those sorts of genes don't exist all over world in underrepresented populations, and affect not only hair pigmentation, but also disease - related traits.»

Still, Dudley feels that evolutionary genetic analysis can help identify the most relevant genes and pathological mechanisms at play in schizophrenia and possibly other mental illnesses that preferentially affect humans — that is, neurodevelopmental disorders related to higher cognition and GABA activity, including autism and attention - deficit / hyperactivity disorder.

Dr. Coyle's Laboratory for Psychiatric and Molecular Neuroscience takes advantage of insights into recently identified genes that confer risk for schizophrenia and related disorders and translates them into genetic mouse models to determine how these mutations affect brain changes as well as function, neurochemistry, and behavior.

They also chose a gene target that might itself be problematic, given that it is part of a closely linked family of globin genes with highly related sequences, making it hard to target one without affecting the others.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

Heterozygous somatic mutations affecting the spliceosome gene SF3B1 drive age - related clonal hematopoiesis, myelodysplastic syndromes (MDS) and other neoplasms.

Together these studies indicate the possibility that prenatal exposure to SSRIs might directly affect the developing brain, perhaps selectively in fetuses having serotonin related gene abnormalities.

It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma) affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»

Remarkable as it seems that it acts in all these pathways, also seems to affect various other enzymes, molecules and genes related to blood sugar control.

With one sample group, they affected a series of genes related to longevity, and created Skrullian Eternals.

To find this out, test mating is done to a dog that is affected with the genetic problem (resulting usually in puppies that are both affected and non-affected carriers) or by inbreeding to a related dog that also doesn't show the signs of being affected (usually litter mates are used) this will usually result in some puppies free of the problem, some puppies as carriers, and some puppies affected if both dogs carry the problem gene (this is not as accurate as breeding to an affected dog, but you are less likely to have to put all the puppies down).

The team honed in on three obesity - related genes to study (the genes they chose have all been shown to affect human weight).

To find this out, test mating is done to a dog that is affected with the genetic problem (resulting usually in puppies that are both affected and non-affected carriers) or by inbreeding to a related dog that also doesn't show the signs of being affected (usually littermates are used) this will usually result in some puppies free of the problem, some puppies as carriers, and some puppies affected if both dogs carry the problem gene (this is not as accurate as breeding to an affected dog, but you are less likely to have to put all the puppies down).

To keep our gene pool diverse, we should not discard dogs from breeding programs simply because they are related to a dog affected with CA.

Two related potassium (K +) channel defects in benign familial neonatal convulsions (BFNC) have recently been identified.9 10 A defect in a receptor for a different neurotransmitter (acetylcholine) has previously been identified in a family with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) 11, which was later shown to affect calcium (Ca +) movement.12 In humans, so far, there has not been any success in identifying genes associated with more common primary epilepsy syndromes such as juvenile absence epilepsy and juvenile myoclonic epilepsy (JME).13 No gene or marker linked to an epilepsy gene has been identified in any dog breed, as yet.